Flavonoids targeting HIF-1: implications on cancer metabolism
| العنوان: | Flavonoids targeting HIF-1: implications on cancer metabolism |
|---|---|
| المؤلفون: | Karel Šmejkal, Kiavash Hushmandi, Milad Ashrafizadeh, Sandra Mersakova, Mehdi Shakibaei, Sepideh Mirzaei, Aranka Brockmueller, Peter Kubatka, Martin Péč, Luciano Saso, Lenka Koklesova, Alena Liskova, Jan Strnadel, Marek Samec, Kevin Zhai, Karol Kajo, Dietrich Büsselberg |
| المصدر: | Cancers, Vol 13, Iss 130, p 130 (2021) Cancers |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Pyruvate dehydrogenase kinase, Review, PKM2, lcsh:RC254-282, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Lactate dehydrogenase, cancer, Glycolysis, Tumor hypoxia, HIF-1, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Warburg effect, 3. Good health, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer cell, flavonoids, Cancer research, flavonoids, pharmacology, pharmacology, Pyruvate kinase |
| الوصف: | Simple Summary This comprehensive review discusses the anticancer effects of plant phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical enzymes contributing to the Warburg effect. Connections between HIF-1 and metabolic reprogramming seem to play a crucial role in cancer progression. The core of presented paper summarizes the current knowledge about the in vitro and in vivo efficacy of flavonoids against aerobic glycolysis and HIF-1 activity. Despite the lack of clinical evidence, we emphasize the possibility of introducing flavonoids (targeting HIF-1) to the clinical research considering predictive, preventive, and/or personalized medical approach. Abstract Tumor hypoxia is described as an oxygen deprivation in malignant tissue. The hypoxic condition is a consequence of an imbalance between rapidly proliferating cells and a vascularization that leads to lower oxygen levels in tumors. Hypoxia-inducible factor 1 (HIF-1) is an essential transcription factor contributing to the regulation of hypoxia-associated genes. Some of these genes modulate molecular cascades associated with the Warburg effect and its accompanying pathways and, therefore, represent promising targets for cancer treatment. Current progress in the development of therapeutic approaches brings several promising inhibitors of HIF-1. Flavonoids, widely occurring in various plants, exert a broad spectrum of beneficial effects on human health, and are potentially powerful therapeutic tools against cancer. Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK). Here, we discuss the results of most recent studies evaluating the impact of flavonoids on HIF-1 accompanied by the regulation of critical enzymes contributing to the Warburg phenotype. Besides, flavonoid effects on glucose metabolism via regulation of HIF-1 activity represent a promising avenue in cancer-related research. At the same time, only more-in depth investigations can further elucidate the mechanistic and clinical connections between HIF-1 and cancer metabolism. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac8d02358d55a9f3ffcc02480bc8b0bTest http://hdl.handle.net/11573/1472439Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8ac8d02358d55a9f3ffcc02480bc8b0b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |