Spontaneous hyaline glomerulopathy in a young Slc:ICR mouse
| العنوان: | Spontaneous hyaline glomerulopathy in a young Slc:ICR mouse |
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| المؤلفون: | Satomi Nishikawa, Hiroko Sato, Akane Kashimura, Tetsuya Sakairi, Mao Mizukawa, Hironobu Nishina |
| المصدر: | Journal of Toxicologic Pathology |
| بيانات النشر: | Japanese Society of Toxicologic Pathology, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, 040301 veterinary sciences, Glomerular deposits, Case Report, Toxicology, Grocott's methenamine silver stain, Stain, glomerulopathy, Pathology and Forensic Medicine, 0403 veterinary science, Lesion, 03 medical and health sciences, 0302 clinical medicine, Glomerulopathy, medicine, Trichrome stain, Hyaline, ICR mouse, Kidney, Chemistry, spontaneous lesion, 04 agricultural and veterinary sciences, medicine.disease, hyaline glomerulopathy, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine.symptom, immunoglobulin |
| الوصف: | Hyaline glomerulopathy is a type of glomerular lesion that occurs in aging mice. Spontaneous hyaline glomerulopathy is rare in young mice. Here, we report spontaneous hyaline glomerulopathy in a young adult (15-week-old) ICR mouse. Necropsy revealed discoloration and roughness of the kidney surface. Microscopically, diffuse glomerular lesions were prominent. Amorphous, eosinophilic materials were deposited globally in the glomeruli. The mesangial region was expanded; however, the mesangial cells showed no proliferation. Thickening of the Bowman's capsule with proliferation of parietal epithelial cells was observed. Glomerular deposits were strongly positive for anti-IgM, anti-IgG, and periodic acid-Schiff stain and were stained red by Masson's trichrome stain. The deposits were negative for anti C3 and stained negatively with Congo red stain. Periodic acid methenamine silver and electron microscopy revealed glomerular deposits limited to intraglomerular capillaries. Based on the histological features, we diagnosed this lesion as hyaline glomerulopathy. This case could improve our understanding of spontaneous lesions in toxicological and pharmacological studies. |
| اللغة: | English |
| تدمد: | 1881-915X 0914-9198 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a811a3f8bf835671d97ce5c5b23a6d7Test http://europepmc.org/articles/PMC7677629Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8a811a3f8bf835671d97ce5c5b23a6d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1881915X 09149198 |
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