Association between telomere length and risk of cancer and non-neoplastic diseases: A Mendelian randomization study
| العنوان: | Association between telomere length and risk of cancer and non-neoplastic diseases: A Mendelian randomization study |
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| المؤلفون: | Collaboration, Telomeres Mendelian Randomization, Haycock, P, Burgess, S, Nounu, A, Zheng, J, Okoli, G, Bowden, J, Wade, K, Timpson, N, Evans, D, Willeit, P, Aviv, A, Gaunt, T, Hemani, G, Mangino, M, Ellis, H, Kurian, K, Pooley, K, Eeles, R, Lee, J, Fang, S, Chen, W, Law, M, Bowdler, L, Iles, M, Yang, Q, Worrall, B, Markus, H, Hung, R, Amos, C, Spurdle, A, Thompson, D, O'Mara, T, Wolpin, B, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, N, Lund, E, Duell, E, Canzian, F, Severi, G, Overvad, K, Gunter, M, Tumino, R, Svenson, U, van Rij, A, Baas, A, Bown, M, Samani, N, van t'Hof, F, Tromp, G, Jones, G, Kuivaniemi, H, Elmore, J, Johansson, M, Mckay, J, Scelo, G, Carreras-Torres, R, Gaborieau, V, Brennan, P, Bracci, P, Neale, R, Olson, S, Gallinger, S, Li, D, Petersen, G, Risch, H, Klein, A, Han, J, Abnet, C, Freedman, N, Taylor, P, Maris, J, Aben, K, Kiemeney, L, Vermeulen, S, Wiencke, J, Walsh, K, Wrensch, M, Rice, T, Turnbull, C, Litchfield, K, Paternoster, L, Standl, M, Abecasis, G, SanGiovanni, J, Li, Y, Mijatovic, V, Sapkota, Y, Low, S, Zondervan, K, Montgomery, G, Nyholt, D, van Heel, D, Hunt, K, Arking, D, Ashar, F, Sotoodehnia, N, Woo, D, Rosand, J, Comeau, M, Brown, W, Silverman, E, Hokanson, J, Cho, M, Hui, J, Ferreira, M, Thompson, P, Morrison, A, Felix, J, Smith, N, Christiano, A, Petukhova, L, Betz, R, Fan, X, Zhang, X, Zhu, C, Langefeld, C, Thompson, S, Wang, F, Lin, X, Schwartz, D, Fingerlin, T, Rotter, J, Cotch, M, Jensen, R, Munz, M, Dommisch, H, Schaefer, A, Han, F, Ollila, H, Hillary, R, Albagha, O, Ralston, S, Zeng, C, Zheng, W, Shu, X, Reis, A, Uebe, S, Hüffmeier, U, Kawamura, Y, Otowa, T, Sasaki, T, Hibberd, M, Davila, S, Xie, G, Siminovitch, K, Bei, J, Zeng, Y, Försti, A, Chen, B, Landi, S, Franke, A, Fischer, A, Ellinghaus, D, Flores, C, Noth, I, Ma, S, Foo, J, Liu, J, Kim, J, Cox, D, Delattre, O, Mirabeau, O, Skibola, C, Tang, C, Garcia-Barcelo, M, Chang, K, Su, W, Chang, Y, Martin, N, Gordon, S, Wade, T, Lee, C, Kubo, M, Cha, P, Nakamura, Y, Levy, D, Kimura, M, Hwang, S, Hunt, S, Spector, T, Soranzo, N, Manichaikul, A, Barr, R, Kahali, B, Speliotes, E, Yerges-Armstrong, L, Cheng, C, Jonas, J, Wong, T, Fogh, I, Lin, K, Powell, J, Rice, K, Relton, C, Martin, R, Davey Smith, G |
| المساهمون: | Erasmus MC other, Epidemiology, Pediatrics |
| المصدر: | Recercat. Dipósit de la Recerca de Catalunya instname Haycock, P C, Burgess, S, Nounu, A, Zheng, J, Okoli, G N, Bowden, J, Wade, K H, Timpson, N J, Evans, D M, Willeit, P, Aviv, A, Gaunt, T R, Hemani, G, Mangino, M, Ellis, H P, Kurian, K M, Pooley, K A, Eeles, R A, Lee, J E, Fang, S, Chen, W V, Law, M H, Bowdler, L M, Iles, M M, Yang, Q, Worrall, B B, Markus, H S, Hung, R J, Amos, C I, Spurdle, A B, Thompson, D J, O'Mara, T A, Wolpin, B, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, N C, Lund, E, Duell, E J, Canzian, F, Severi, G, Overvad, K, Gunter, M J, Tumino, R, Brennan, P, Paternoster, L, Soranzo, N, Relton, C L, Martin, R M, Davey Smith, G 2017, ' Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases : A Mendelian Randomization Study ', JAMA Oncology, vol. 3, no. 5, pp. 636-651 . https://doi.org/10.1001/jamaoncol.2016.5945Test Dipòsit Digital de la UB Universidad de Barcelona Jama Oncology, 3, 636-651 JAMA Oncol. 3, 636-651 (2017) Jama Oncology, 3, 5, pp. 636-651 Haycock, P C, Burgess, S, Nounu, A, Zheng, J, Okoli, G N, Bowden, J, Wade, K H, Timpson, N J, Evans, D M, Willeit, P, Aviv, A, Gaunt, T R, Hemani, G, Mangino, M, Ellis, H P, Kurian, K M, Pooley, K A, Eeles, R A, Lee, J E, Fang, S, Chen, W V, Law, M H, Bowdler, L M, Iles, M M, Yang, Q, Worrall, B B, Markus, H S, Hung, R J, Amos, C I, Spurdle, A B, Thompson, D J, O'Mara, T A, Wolpin, B M, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, N C, Lund, E, Duell, E J, Canzian, F, Severi, G, Overvad, K, Gunter, M J, Tumino, R, Svenson, U, van Rij, A, Baas, A F, Bown, M J, Samani, N J, van t'Hof, F N G & Telomeres Mendelian Randomization Collaboration 2017, ' Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases : A Mendelian Randomization Study ', JAMA Oncology, vol. 3, no. 5, pp. 636-651 . https://doi.org/10.1001/jamaoncol.2016.5945Test Haycock, P C, Burgess, S, Nounu, A, Zheng, J, Okoli, G N, Bowden, J, Wade, K H, Timpson, N J, Evans, D M, Willeit, P, Aviv, A, Gaunt, T R, Hemani, G, Mangino, M, Ellis, H P, Kurian, K M, Pooley, K A, Eeles, R A, Lee, J E, Fang, S, Chen, W V, Law, M H, Bowdler, L M, Iles, M M, Yang, Q, Worrall, B B, Markus, H S, Hung, R J, Amos, C I, Spurdle, A B, Thompson, D J, O'Mara, T A, Wolpin, B, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, N C, Lund, E, Duell, E J, Canzian, F, Severi, G, Overvad, K, Gunter, M J, Tumino, R, Svenson, U, van Rij, A, Baas, A F, Bown, M J & Albagha, O & Ralston, S H 2017, ' Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases : A Mendelian Randomization Study ', JAMA Oncology, vol. 3, no. 5, pp. 636-651 . https://doi.org/10.1001/jamaoncol.2016.5945Test JAMA Oncology, 3(5), 636-651. American Medical Association |
| بيانات النشر: | American Medical Association, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Cancer Research, Single-nucleotide polymorphism, Genome-wide association study, Disease, Bioinformatics, Polymorphism, Single Nucleotide, Risk Assessment, Article, 03 medical and health sciences, Telomere Homeostasis, SDG 3 - Good Health and Well-being, Neoplasms, Mendelian randomization, Journal Article, medicine, Humans, Genetic Predisposition to Disease, Càncer, Germ-Line Mutation, Aged, Cancer, Aged, 80 and over, business.industry, Nucleotides, Odds ratio, Mendelian Randomization Analysis, Middle Aged, Telomere, medicine.disease, Nucleòtids, 030104 developmental biology, Stem cell division, Oncology, Cardiovascular Diseases, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Female, ICEP, business, Genome-Wide Association Study, Bristol Population Health Science Institute |
| الوصف: | Importance The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. Objective To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. Data Sources Genomewide association studies (GWAS) published up to January 15, 2015. Study Selection GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. Data Extraction and Synthesis Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. Main Outcomes and Measures Odds ratios (ORs) and 95%confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. Results Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [95%CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [95%CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [95%CI, 0.49-0.81]), celiac disease (OR, 0.42 [95%CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [95%CI, 0.05-0.15]). Conclusions and Relevance It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2374-2437 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2000a873a3758f4f5146b904102b8dTest https://ora.ox.ac.uk/objects/uuid:fa418653-b9ce-4f1f-bc60-a388ffad4b6bTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8a2000a873a3758f4f5146b904102b8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23742437 |
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