Depressed distal tubule acidification corrects chloride-deplete alkalosis in rats
| العنوان: | Depressed distal tubule acidification corrects chloride-deplete alkalosis in rats |
|---|---|
| المؤلفون: | David E. Wesson |
| المصدر: | American Journal of Physiology-Renal Physiology. 259:F636-F644 |
| بيانات النشر: | American Physiological Society, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Alkalosis, Physiology, Bicarbonate, Metabolic alkalosis, Blood Pressure, Punctures, Acid–base homeostasis, Absorption, chemistry.chemical_compound, Chlorides, Internal medicine, medicine, Animals, Kidney Tubules, Distal, Ion transporter, Kidney, Reabsorption, Furosemide, Rats, Inbred Strains, medicine.disease, Rats, Bicarbonates, medicine.anatomical_structure, Endocrinology, chemistry, Regression Analysis, Female, Acids, medicine.drug |
| الوصف: | We investigated the relative contributions made by the proximal and distal tubule to the correction of Cl-deplete metabolic alkalosis induced by systemic administration of NaCl. Free-flow micropuncture was used to examine net bicarbonate reabsorption in superficial proximal and distal tubules of anesthetized Munich-Wistar rats during maintenance and correction of chronic furosemide-induced Cl-deplete metabolic alkalosis. The distal tubule of animals with correcting vs. maintained alkalosis had a lower fractional reabsorption of bicarbonate (38 vs. 75%, P less than 0.001) and a lower slope of the linear regression comparing absorption to delivered load (0.48 vs. 0.99, P less than 0.02). By contrast, proximal tubule of animals with correcting vs. maintained alkalosis had fractional reabsorption (85 vs. 90%, P = 0.07) and slopes of the regression comparing reabsorption to filtered load (1.09 vs. 0.98, P = 0.48) that were not different. The data indicate that correction of Cl-deplete metabolic alkalosis induced by NaCl administration involves a qualitative decreased in bicarbonate reabsorption in distal tubule with maintenance of the same load-dependent relationship for bicarbonate reabsorption in proximal tubule. |
| تدمد: | 1522-1466 1931-857X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a18663f59500a0e56d07d63a161c3e9Test https://doi.org/10.1152/ajprenal.1990.259.4.f636Test |
| رقم الانضمام: | edsair.doi.dedup.....8a18663f59500a0e56d07d63a161c3e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221466 1931857X |
|---|