Anti-metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA-MB-231 cells
| العنوان: | Anti-metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA-MB-231 cells |
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| المؤلفون: | Jicheng Liu, Chao Sun, Liling Yue, Xiaohui Du, Yu Lin, Hongxia Cui, Hongyan Yang |
| المصدر: | Oncology Letters. 10:1117-1122 |
| بيانات النشر: | Spandidos Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | MAPK/ERK pathway, Cancer Research, biology, Oncogene, Kinase, business.industry, Integrin, Articles, medicine.disease, Metastasis, Focal adhesion, Oncology, Immunology, medicine, biology.protein, Cancer research, Cell adhesion, Protein kinase A, business |
| الوصف: | Tumor metastasis is the main cause of mortality in cancer patients. However, no effective therapies are currently available to prevent metastasis. Cell adhesion to the extracellular matrix (ECM) is crucial in cancer progression and metastasis. Thus, suppression of cell adhesion may be an effective therapeutic strategy for the prevention of metastasis. In the present study, the anti-adhesion and anti-invasion effects of jolkinolide B, a diterpenoid compound from Euphorbia fischeriana Steud, that were exerted through suppression of β1-integrin expression and phosphorylation of focal adhesion kinase (FAK) were examined in human breast cancer MDA-MB-231 cells. Jolkinolide B inhibited the adhesion of MDA-MB-231 cells to fibronectin but not to poly-L-lysine. In addition, jolkinolide B inhibited extracellular signal-regulated kinase (ERK) phosphorylation. U0126, an ERK inhibitor, also suppressed the invasion and adhesion of MDA-MB-231 cells. Overall, the present data demonstrated that jolkinolide B is a novel inhibitor of FAK-mediated signaling pathways that is involved in decreasing cell adhesion and invasion. Mitogen-activated protein kinase/ERK kinase may play a critical role in these effects, indicating that jolkinolide B possesses therapeutic potential for the treatment of breast cancer metastasis. |
| تدمد: | 1792-1082 1792-1074 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a05fec142752006ecbd3605acc3e866Test https://doi.org/10.3892/ol.2015.3310Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8a05fec142752006ecbd3605acc3e866 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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