ST2 and REG3α as Predictive Biomarkers After Haploidentical Stem Cell Transplantation Using Post-transplantation High-Dose Cyclophosphamide
| العنوان: | ST2 and REG3α as Predictive Biomarkers After Haploidentical Stem Cell Transplantation Using Post-transplantation High-Dose Cyclophosphamide |
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| المؤلفون: | Laura Solán, Mi Kwon, Diego Carbonell, Nieves Dorado, Pascual Balsalobre, David Serrano, María Chicano-Lavilla, Javier Anguita, Jorge Gayoso, José Luis Díez-Martín, Carolina Martínez-Laperche, Ismael Buño |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 10 (2019) |
| بيانات النشر: | Frontiers Media S.A., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_treatment, Graft vs Host Disease, Pancreatitis-Associated Proteins, Hematopoietic stem cell transplantation, Gastroenterology, 0302 clinical medicine, graft vs. host disease, Immunology and Allergy, Medicine, Original Research, Incidence (epidemiology), haploidentical, Hematopoietic Stem Cell Transplantation, Middle Aged, Post transplant, Survival Rate, surgical procedures, operative, Toxicity, Cohort, Acute Disease, Female, Stem cell, medicine.drug, lcsh:Immunologic diseases. Allergy, Adult, medicine.medical_specialty, Cyclophosphamide, Adolescent, Immunology, Disease-Free Survival, 03 medical and health sciences, non-relapse mortality, Internal medicine, Humans, hematopoietic cell transplantation, Aged, Retrospective Studies, business.industry, biomarkers, ST2, Interleukin-1 Receptor-Like 1 Protein, Transplantation, 030104 developmental biology, Transplantation, Haploidentical, REG3α, business, lcsh:RC581-607, 030215 immunology |
| الوصف: | Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative procedure for several hematological malignancies. Haploidentical HSCT (haplo-HSCT) using high-dose post-transplantation cyclophosphamide (PTCy) makes transplantation possible for patients with no HLA-matched sibling donor. However, this treatment can cause complications, mainly infection, graft-vs.-host disease (GVHD), and conditioning-related toxicity. In recent years, different biomarkers in the form of tissue-specific proteins have been investigated; these may help us to predict complications of allo-HSCT. In this study we explored two such biomarkers, suppression of tumorigenicity 2 (ST2) and regenerating islet-derived 3α (REG3α), in the largest series reported of T cell-replete haplo-HSCT with PTCy. Plasma samples drawn from 87 patients at days +15 and +30 were analyzed. ST2 and REG3α levels at day +15 were not associated with post-transplant complications. ST2 levels at day +30 were higher in patients with grade II-IV acute GVHD, mainly those who received reduced intensity conditioning (RIC; median 2,503 vs. 1,830 ng/ml; p = 0.04). Of note, patients with higher plasma ST2 levels at day +30 also presented a higher incidence of non-relapse mortality (HR, 7.9; p = 0.004) and lower 2-year overall survival (25 vs. 44 months; p = 0.02) than patients with lower levels. Patients with REG3α levels higher than 1,989 pg/ml at day +30 presented a higher incidence of acute gastrointestinal GVHD in the whole cohort (HR, 8.37; p = 0.003) and in the RIC cohort (HR 6.59; p = 0.01). These data suggest that measurement of ST2 and REG3α might be useful for the prognosis and prediction of complications in patients undergoing haplo-HSCT with PTCy. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c99cb06ec86c305c324586b7ddfccfTest http://europepmc.org/articles/PMC6794466Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....89c99cb06ec86c305c324586b7ddfccf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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