Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
| العنوان: | Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances |
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| المؤلفون: | Zhanhong Xie, Hongsheng Deng, Zisheng Chen, Shen Lao, Wenhua Liang, Yongmei Zheng, Maojin Yao, Xiwen Liu, Miao He, Xiuyu Cai, Qihua He, Jianxing He, Jun Liu, Xiaoyan Liu |
| المصدر: | Transl Lung Cancer Res |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Tumor microenvironment, business.industry, government.form_of_government, Review Article, medicine.disease, Lymphangiogenesis, Metastasis, 03 medical and health sciences, Lymphatic Endothelium, 030104 developmental biology, 0302 clinical medicine, Lymphatic system, medicine.anatomical_structure, Oncology, Tumor progression, 030220 oncology & carcinogenesis, government, Lymphatic vessel, Cancer research, Medicine, business, Lung cancer |
| الوصف: | BACKGROUND: As lymphatic vessel is a major route for solid tumor metastasis, they are considered an essential part of tumor drainage conduits. Apart from forming the walls of lymphatic vessels, lymphatic endothelial cells (LECs) have been found to play multiple other roles in the tumor microenvironment, calling for a more in-depth review. We hope that this review may help researchers gain a detailed understanding of this fast-developing field and shed some light upon future research. METHODS: To achieve an informative review of recent advance, we carefully searched the Medline database for English literature that are openly published from the January 1995 to December 2020 and covered the topic of LEC or lymphangiogenesis in tumor progression and therapies. Two different authors independently examined the literature abstracts to exclude possible unqualified ones, and 310 papers with full texts were finally retrieved. RESULTS: In this paper, we discussed the structural and molecular basis of tumor-associated LECs, together with their roles in tumor metastasis and drug therapy. We then focused on their impacts on tumor cells, tumor stroma, and anti-tumor immunity, and the molecular and cellular mechanisms involved. Special emphasis on lung cancer and possible therapeutic targets based on LECs were also discussed. CONCLUSIONS: LECs can play a much more complex role than simply forming conduits for tumor cell dissemination. Therapies targeting tumor-associated lymphatics for lung cancer and other tumors are promising, but more research is needed to clarify the mechanisms involved. |
| تدمد: | 2226-4477 2218-6751 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897adfb5f41bc29022d7a4299276e0d5Test https://doi.org/10.21037/tlcr-21-40Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....897adfb5f41bc29022d7a4299276e0d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22264477 22186751 |
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