The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the 13C-ketoisocaproate breath test
التفاصيل البيبلوغرافية
العنوان:
The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the 13C-ketoisocaproate breath test
Hepatic mitochondrial function (HMF) assessed by the 13C-ketoisocaproate breath test (13C-KICA BT) has been previously shown to be significantly associated with the severity of biopsy proven non-alcoholic fatty liver disease (NAFLD). However, it is uncertain whether any perturbation in HMF relates specifically to severity of liver disease or factors associated with metabolic syndrome within non-alcoholic fatty liver disease (NAFLD). Our aim was to investigate whether there was any change in HMF assessed by 13C-KICA BT in patients with NAFLD compared to control subjects, and to assess the factors that are independently associated with HMF. Methods: 77 patients with NAFLD and 11 healthy control subjects were studied. HMF was assessed using 13C-KICA BT and expressed as cumulative % 13C-dose recovered on breath over 1hr (cPDR over 1hr). Liver fat and fibrosis was assessed by transient elastography. Multi-variable linear regression modelling was undertaken to test the independence of associations with HMF. Results: HMF (cPDR over 1hr) was lower in NAFLD compared to controls [13.4% (4.8) v. 21.0% (6.3); p Conclusions: In patients with NAFLD (compared to healthy subjects), there was a reduction in HMF assessed by the 13C-KICA BT. Furthermore, in patients with NAFLD, HMF is independent and inversely associated with age, waist and hip circumference, AST and diabetes status.
