Polymorphisms in Neuronal Growth Regulator 1 and Otoancorin Alternate the Susceptibility to Lung Cancer in Chinese Nonsmoking Females
| العنوان: | Polymorphisms in Neuronal Growth Regulator 1 and Otoancorin Alternate the Susceptibility to Lung Cancer in Chinese Nonsmoking Females |
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| المؤلفون: | Wen Tian, Ludan Zhang, Baosen Zhou |
| المصدر: | DNA and Cell Biology. 39:1657-1663 |
| بيانات النشر: | Mary Ann Liebert Inc, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Oncology, China, medicine.medical_specialty, Lung Neoplasms, Cell Adhesion Molecules, Neuronal, Single-nucleotide polymorphism, Adenocarcinoma, Biology, GPI-Linked Proteins, Polymorphism, Single Nucleotide, Internal medicine, Genotype, Genetics, medicine, Humans, Risk factor, Lung cancer, Molecular Biology, Aged, Neuronal growth regulator 1, Non-Smokers, Cell Biology, General Medicine, Odds ratio, Middle Aged, medicine.disease, Lung cancer susceptibility, Female |
| الوصف: | Cell adhesion molecules (CAMs) play crucial roles in the genesis and progress of tumor. We investigated the effects of single nucleotide polymorphisms (SNPs) of CAMs, neuronal growth regulator 1 (NEGR1), and Otoancorin (OTOA) on lung cancer susceptibility in Chinese nonsmoking females. Logistic regression and Cox regression analyses were conducted to investigate the effects of SNPs and environmental factors. For rs3102911, genotype TT carriers decreased the risk of lung cancer with an odds ratio (OR) of 0.635. AA genotypes of rs741718 increased the risk of lung cancer with an OR of 3.527. In stratified analysis, genotype AA carriers of rs741718 had a high susceptibility to lung adenocarcinoma compared with GG and AG genotypes. Analyses of association between SNPs and clinical characteristics revealed that rs3102911 as a protective factor and rs741718 as a risk factor influenced the lung cancer occurrence and progression in nonsmoking females. |
| تدمد: | 1557-7430 1044-5498 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fcc3e5a6e4b77fc7e868ee1d0f42cfTest https://doi.org/10.1089/dna.2020.5654Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....88fcc3e5a6e4b77fc7e868ee1d0f42cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577430 10445498 |
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