Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3
| العنوان: | Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3 |
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| المؤلفون: | Hongli Yang, Zhihong Zhao, Guixiang Liao, Xiaming Li |
| المصدر: | Journal of International Medical Research, Vol 48 (2020) The Journal of International Medical Research |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Honokiol, ionizing irradiation, Medicine (General), SIRT3, Radiation induced, sirtuin 3, medicine.disease_cause, Biochemistry, Lignans, Pre-Clinical Research Report, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, R5-920, Medicine, Animals, Zebrafish, radiation-induced brain injury, chemistry.chemical_classification, reactive oxygen species, Reactive oxygen species, biology, business.industry, Biochemistry (medical), Biphenyl Compounds, Brain, Cell Biology, General Medicine, Ionizing irradiation, biology.organism_classification, Cell biology, Oxidative Stress, 030104 developmental biology, chemistry, cyclooxygenase-2, 030220 oncology & carcinogenesis, Brain Injuries, business, Oxidative stress |
| الوصف: | Objective Sirtuin 3 (SIRT3) plays a vital role in regulating oxidative stress in tissue injury. The aim of this study was to evaluate the radioprotective effects of honokiol (HKL) in a zebrafish model of radiation-induced brain injury and in HT22 cells. Methods The levels of reactive oxygen species (ROS), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) were evaluated in the zebrafish brain and HT22 cells. The expression levels of SIRT3 and cyclooxygenase-2 (COX-2) were measured using western blot assays and real-time polymerase chain reaction (RT-PCR). Results HKL treatment attenuated the levels of ROS, TNF-α, and IL-1β in both the in vivo and in vitro models of irradiation injury. Furthermore, HKL treatment increased the expression of SIRT3 and decreased the expression of COX-2. The radioprotective effects of HKL were achieved via SIRT3 activation. Conclusions HKL attenuated oxidative stress and pro-inflammatory responses in a SIRT3-dependent manner in radiation-induced brain injury. |
| اللغة: | English |
| تدمد: | 1473-2300 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8824fe445ef750f8ac887973a30f9d0cTest https://doaj.org/article/3f3e61c31c824e9080b6e3f3388af301Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8824fe445ef750f8ac887973a30f9d0c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 |
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