Recovery of the Sensitivity to Anti-PD-1 Antibody by Celecoxib in Lung Cancer
| العنوان: | Recovery of the Sensitivity to Anti-PD-1 Antibody by Celecoxib in Lung Cancer |
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| المؤلفون: | Kunihiko Kobayashi, Kyoichi Kaira, Hiroshi Kagamu |
| المصدر: | Anticancer Research. 40:5309-5311 |
| بيانات النشر: | Anticancer Research USA Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, T-Lymphocytes, Programmed Cell Death 1 Receptor, Immunomodulation, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Downregulation and upregulation, Internal medicine, Biomarkers, Tumor, medicine, Carcinoma, Humans, Lung cancer, Cyclooxygenase 2 Inhibitors, business.industry, Anti pd 1, Drug Synergism, General Medicine, Middle Aged, medicine.disease, Primary tumor, Sequential treatment, ErbB Receptors, Treatment Outcome, Celecoxib, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Radiography, Thoracic, Nivolumab, business, medicine.drug |
| الوصف: | Background/aim Experimental studies have shown that celecoxib is related to the downregulation of Tregs and an increase in the therapeutic efficacy of PD-1 inhibitors; however, such effect has not been shown in human cancers. Our report confirmed the synergistic effect of celecoxib with a PD-1 inhibitor. Case report A 57-year-old male with advanced pulmonary adenocarcinoma was treated with nivolumab monotherapy as 5th line sequential treatment. Although the patient experienced tumor remission, regrowth of the primary tumor was observed and he complained of lumbar pain. Therefore, celecoxib (400 mg/day) was initiated without cessation of nivolumab. Chest radiography revealed a marked shrinkage of the primary site, with a decreasing trend of carcinoma embryonic antigen. Conclusion This is the report of a case of recovery of sensitivity to nivolumab by additional treatment with celecoxib. |
| تدمد: | 1791-7530 0250-7005 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881315dd91d60106a65e8dfe86781c75Test https://doi.org/10.21873/anticanres.14537Test |
| رقم الانضمام: | edsair.doi.dedup.....881315dd91d60106a65e8dfe86781c75 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
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