Assessment of hypercoagulability markers and lipid levels in postmenopausal women undergoing either oral or transdermal hormone replacement therapy
| العنوان: | Assessment of hypercoagulability markers and lipid levels in postmenopausal women undergoing either oral or transdermal hormone replacement therapy |
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| المؤلفون: | Túlio César Alvim, Ana Paula Fernandes, Luci Maria Sant'Ana Dusse, Maria das Graças Carvalho, George da Silva Teixeira, Marinez O. Sousa, Jarbas E. Cardoso, Daniela Amorim Melgaço Guimarães, Romerson Martins Franco, Hilton de Almeida Franco |
| المصدر: | Journal of Thrombosis and Thrombolysis. 27:135-140 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | medicine.medical_specialty, genetic structures, Hormone Replacement Therapy, medicine.medical_treatment, Administration, Oral, Blood lipids, Administration, Cutaneous, Gastroenterology, Internal medicine, medicine, Humans, Thrombophilia, Blood Coagulation, Aged, Transdermal, Hemostasis, Hematology, Postmenopausal women, business.industry, Fibrinolysis, Hormone replacement therapy (menopause), Plasma levels, Middle Aged, medicine.disease, Lipids, Thrombosis, eye diseases, Postmenopause, Endocrinology, Female, sense organs, Cardiology and Cardiovascular Medicine, business, Biomarkers, Brazil |
| الوصف: | Background This study investigated the effect of either oral or transdermal hormone replacement therapy (HRT) on haemostatic, fibrinolytic and lipid profiles in a group of Brazilian women 3 months after beginning treatment by comparing these results with those obtained immediately before HRT. Methods Plasma levels of TAT, DDi, F1+2, PC, PS, AT, PAI-1 and serum lipids were determined in blood samples collected from 24 women undergoing oral HRT and from 11 women undergoing transdermal HRT. Results Significant increases in DDi and F1+2 plasma levels were observed after 3 months of oral HRT, while PS levels decreased. After transdermal HRT, a significant decrease was observed only for AT levels. Conclusion After 3 months of oral HRT and in the absence of major genetic and acquired risk factors, women displayed a predisposition for activation of blood coagulation, and an increased activity of the fibrinolytic system. Oral HRT seemed to be more effective in predisposing haemostatic changes as compared to transdermal. |
| تدمد: | 1573-742X 0929-5305 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88012510f12ff662d7c61fbe914c3323Test https://doi.org/10.1007/s11239-007-0169-7Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....88012510f12ff662d7c61fbe914c3323 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1573742X 09295305 |
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