Transcatheter Aortic Valve Replacement Is Associated with Less Oxidative Stress and Faster Recovery of Antioxidant Capacity than Surgical Aortic Valve Replacement
| العنوان: | Transcatheter Aortic Valve Replacement Is Associated with Less Oxidative Stress and Faster Recovery of Antioxidant Capacity than Surgical Aortic Valve Replacement |
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| المؤلفون: | Bartłomiej Perek, Mateusz Puślecki, Anna Komosa, Marek Grygier, Przemysław Niedzielski, Zbigniew Krasiński, Tatiana Mularek-Kubzdela, Barbara Poniedziałek, Marcin Misterski, Jolanta M. Siller-Matula, Mariola Ropacka-Lesiak, Anna Olasińska-Wiśniewska, Piotr Rzymski, Maciej Lesiak |
| المصدر: | Journal of Clinical Medicine Volume 8 Issue 9 Journal of Clinical Medicine, Vol 8, Iss 9, p 1364 (2019) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Transcatheter aortic, genetic structures, Thiobarbituric acid, medicine.medical_treatment, Urology, lcsh:Medicine, 030204 cardiovascular system & hematology, medicine.disease_cause, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Aortic valve replacement, Valve replacement, Lactate dehydrogenase, medicine, TBARS, oxidative stress, 030212 general & internal medicine, transcatheter aortic valve implantation, business.industry, lcsh:R, General Medicine, medicine.disease, Antioxidant capacity, chemistry, total antioxidant capacity, business, Oxidative stress, surgical aortic valve replacement |
| الوصف: | The objective of this study was to compare oxidative stress indices in 24 patients (mean ± SD age 71 ± 13 years) undergoing surgical aortic valve replacement (SAVR) versus transcatheter aortic valve replacement (TAVR). Serum total antioxidant capacity (TAC), copper/zinc ratio (Cu/Zn), activity of lactate dehydrogenase (LDH), and thiobarbituric acid reactive substances (TBARS) were assessed at four different time-points: pre-procedure, immediately post-procedure, and one day and two days after the procedure. All oxidative stress parameters were comparable in both groups pre-procedure. TAC decreased significantly when assessed immediately after procedures in both groups (p < 0.001) however, the magnitude of the reduction was more pronounced after SAVR (88% decrease from baseline: 1.8 ± 0.1 vs. 0.2 ± 0.03 mM) compared to TAVR procedures (53% decrease from baseline: 1.9 ± 0.1 vs. 1.0 ± 0.1 mM p < 0.001). TAC returned to baseline two days after TAVR in all patients, but was still reduced by 55% two days after SAVR. In concordance, TBARS levels and Cu/Zn ratio increased significantly with maximum levels immediately after procedures in both groups (p < 0.001), but the magnitude of the increase was significantly higher in SAVR compared to TAVR (TBARS: 3.93 ± 0.61 µ M vs. 1.25 ± 0.30 µ M, p = 0.015 Cu/Zn ratio: 2.33 ± 0.11 vs. 1.80 ± 0.12 0.001). Two days after the procedure, TBARS levels and the Cu/Zn ratio returned to baseline after TAVR, with no full recovery after SAVR. TAVR is associated with a lesser redox imbalance and faster recovery of antioxidant capacity compared to SAVR. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| DOI: | 10.3390/jcm8091364 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bc608136b1b4222922ad02ceb9c1f9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....87bc608136b1b4222922ad02ceb9c1f9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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| DOI: | 10.3390/jcm8091364 |