Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease
| العنوان: | Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease |
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| المؤلفون: | Ying Shao, Xiaoyu Ma, Huiwen Ren, Qiuyue Wang, Can Wu, Chuan Lv |
| المصدر: | Endocrine. 55:130-138 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, Vascular Endothelial Growth Factor A, 0301 basic medicine, China, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Kidney, Severity of Illness Index, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Insulin resistance, Sirtuin 1, Diabetes mellitus, Internal medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Renal Insufficiency, Aged, Glycated Hemoglobin, Creatinine, Proteinuria, business.industry, Middle Aged, Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, MicroRNAs, Cross-Sectional Studies, 030104 developmental biology, Diabetes Mellitus, Type 2, chemistry, Disease Progression, Uric acid, Female, Glycated hemoglobin, Insulin Resistance, medicine.symptom, business, Biomarkers |
| الوصف: | The aim of this study is to investigate the correlation between serum microRNA-217 and the severity of diabetic kidney disease determined by albuminuria. Four hundred ninety five type 2 diabetes patients were divided into three groups: normoalbuminuric group, microalbuminuric group, and macroalbuminuric group. Serum microRNA-217 levels were validated by real-time polymerase chain reaction. Serum silent information regulator 1, Hypoxia-inducible factor-1α and vascular endothelial growth factor were determined by enzyme-linked immunosorbent assay. Compared with control, serum microRNA-217 levels were significantly increased in type 2 diabetes patients and gradually increased in patients of normoalbuminuric, microalbuminuric, and macroalbuminuric groups (P |
| تدمد: | 1559-0100 1355-008X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87aa2dea04ec583c10cbf71c1c61ea6eTest https://doi.org/10.1007/s12020-016-1069-4Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....87aa2dea04ec583c10cbf71c1c61ea6e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590100 1355008X |
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