Molecular pathology of tumors of the central nervous system
| العنوان: | Molecular pathology of tumors of the central nervous system |
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| المؤلفون: | Loudy P Priesterbach-Ackley, Pieter Wesseling, Bjarne Winther Kristensen, Jeanette Krogh Petersen |
| المصدر: | Annals of Oncology, 30(8), 1265. Oxford University Press Kristensen, B W, Priesterbach-Ackley, L P, Petersen, J K & Wesseling, P 2019, ' Molecular Pathology of Tumors of the Central Nervous System ', Annals of Oncology, vol. 30, no. 8, pp. 1265-1278 . https://doi.org/10.1093/annonc/mdz164Test Kristensen, B W, Priesterbach-Ackley, L P, Petersen, J K & Wesseling, P 2019, ' Molecular pathology of tumors of the central nervous system ', Annals of Oncology, vol. 30, no. 8, pp. 1265-1278 . https://doi.org/10.1093/annonc/mdz164Test Annals of Oncology |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Ependymoma, Solitary fibrous tumor, Neoplasms, Germ Cell and Embryonal/diagnosis, 0302 clinical medicine, molecular pathology, glioma, Antineoplastic Combined Chemotherapy Protocols, Molecular Targeted Therapy, Molecular pathology, Brain Neoplasms, Brain, Glioma/diagnosis, Hematology, Neoplasms, Germ Cell and Embryonal, Prognosis, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Survival Rate, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Atypical teratoid rhabdoid tumor, integrated diagnosis, IDH1, embryonal tumor, Reviews, Drug Resistance, Neoplasm/genetics, Antineoplastic Combined Chemotherapy Protocols/pharmacology, medulloblastoma, Biomarkers, Tumor/analysis, 03 medical and health sciences, Glioma, medicine, Biomarkers, Tumor, Journal Article, Humans, Brain/pathology, Hemangiopericytoma, Medulloblastoma, Brain Neoplasms/diagnosis, business.industry, DNA Methylation, medicine.disease, 030104 developmental biology, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic/drug effects, Mutation, Cancer research, business, Molecular Targeted Therapy/methods, CNS tumor |
| الوصف: | Since the update of the 4th edition of the WHO Classification of Central Nervous System (CNS) Tumors published in 2016, particular molecular characteristics are part of the definition of a subset of these neoplasms. This combined ‘histo-molecular’ approach allows for a much more precise diagnosis of especially diffuse gliomas and embryonal CNS tumors. This review provides an update of the most important diagnostic and prognostic markers for state-of-the-art diagnosis of primary CNS tumors. Defining molecular markers for diffuse gliomas are IDH1/IDH2 mutations, 1p/19q codeletion and mutations in histone H3 genes. Medulloblastomas, the most frequent embryonal CNS tumors, are divided into four molecularly defined groups according to the WHO 2016 Classification: wingless/integrated (WNT) signaling pathway activated, sonic hedgehog (SHH) signaling pathway activated and tumor protein p53 gene (TP53)-mutant, SHH-activated and TP53-wildtype, and non-WNT/non-SHH-activated. Molecular characteristics are also important for the diagnosis of several other CNS tumors, such as RELA fusion-positive subtype of ependymoma, atypical teratoid rhabdoid tumor (AT/RT), embryonal tumor with multilayered rosettes, and solitary fibrous tumor/hemangiopericytoma. Immunohistochemistry is a helpful alternative for further molecular characterization of several of these tumors. Additionally, genome-wide methylation profiling is a very promising new tool in CNS tumor diagnostics. Much progress has thus been made by translating the most relevant molecular knowledge into a more precise clinical diagnosis of CNS tumors. Hopefully, this will enable more specific and more effective therapeutic approaches for the patients suffering from these tumors. |
| وصف الملف: | text/plain; application/pdf; image/pdf |
| اللغة: | English |
| تدمد: | 0923-7534 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878a37f0fbef4c9facbc0f76ef647cdcTest https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072721345&origin=inwardTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....878a37f0fbef4c9facbc0f76ef647cdc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09237534 |
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