Increased levels of tPA antigen and tPA/PAI-1 complex in myotonic dystrophy
| العنوان: | Increased levels of tPA antigen and tPA/PAI-1 complex in myotonic dystrophy |
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| المؤلفون: | Tommy Olsson, Anders Johansson, Kurt Boman, Håkan Forsberg, Kristina Cederquist |
| المصدر: | Journal of Internal Medicine. 249:503-510 |
| بيانات النشر: | Wiley, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Blood lipids, Adipose tissue, Enzyme-Linked Immunosorbent Assay, Tissue plasminogen activator, Statistics, Nonparametric, chemistry.chemical_compound, Insulin resistance, Internal medicine, Plasminogen Activator Inhibitor 1, Electric Impedance, Internal Medicine, medicine, Humans, Insulin, Myotonic Dystrophy, Antigens, Triglyceride, business.industry, Metabolic disorder, medicine.disease, Lipids, Endocrinology, chemistry, Case-Control Studies, Tissue Plasminogen Activator, Body Composition, Regression Analysis, Female, Metabolic syndrome, business, medicine.drug |
| الوصف: | Johansson A, Boman K, Cederquist K, Forsberg H, Olsson T (Umea University Hospital, Umea, Skelleftea County Hospital, Skelleftea, and Boden Hospital, Boden, Sweden). Increased levels of tPA antigen and tPA/PAI-1 complex in myotonic dystrophy. J Intern Med 2001; 249: 503–510. Objective. To assess the fibrinolytic system in myotonic dystrophy (DM1), a disease connected to features of the metabolic syndrome, including a prominent insulin resistance, increased body fat mass, and hypertriglyceridaemia. We hypothesized that abnormalities in the fibrinolytic system are linked to metabolic dysfunction in DM1. Design. Circulating morning levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor type 1 (PAI-1) antigens, tPA/PAI-1 complex, lipids and insulin were determined. Genetic analyses, including calculation of allele size, were performed in all patients. Body fat mass was estimated with bioelectrical impedance analysis. Setting. Out-patient clinic in collaboration with Umea University Hospital. Subjects. A total of 42 otherwise healthy patients with DM1 (22 men, 20 women; median age 41.5 years) and 50 controls (27 men, 23 women; median age 42.0 years). Main outcome measures. The tPA and PAI-1 antigens, tPA/PAI-1 complex, blood lipids and body fat mass. Results. The tPA antigen and tPA/PAI-1 complex levels were significantly increased in DM1 patients (P |
| تدمد: | 1365-2796 0954-6820 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8712710d57683c024461f751389eef62Test https://doi.org/10.1046/j.1365-2796.2001.00832.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8712710d57683c024461f751389eef62 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652796 09546820 |
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