Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide
| العنوان: | Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide |
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| المؤلفون: | Robert Dantzer, Keith W. Kelley, S. Park, Robert H. McCusker, Marcus A. Lawson |
| المصدر: | Journal of Neuroinflammation, Vol 8, Iss 1, p 179 (2011) Journal of Neuroinflammation |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, medicine.medical_specialty, Lipopolysaccharide, medicine.medical_treatment, Immunology, Motor Activity, lcsh:RC346-429, Eating, Mice, Cellular and Molecular Neuroscience, Insulin-like growth factor, chemistry.chemical_compound, sickness, Neurotrophic factors, Internal medicine, medicine, Animals, Indoleamine-Pyrrole 2,3,-Dioxygenase, Nerve Growth Factors, Insulin-Like Growth Factor I, lcsh:Neurology. Diseases of the nervous system, Sickness behavior, Depression (differential diagnoses), chemistry.chemical_classification, depression-like behavior, Behavior, Animal, Depression, business.industry, Research, General Neuroscience, Growth factor, Body Weight, lipopolysaccharide, Tryptophan, Brain, IGF-I, Endocrinology, Enzyme, Neurology, chemistry, Exploratory Behavior, Cytokines, Peptides, business, Biomarkers, Injections, Intraperitoneal |
| الوصف: | Centrally administered insulin-like growth factor (IGF)-I has anti-depressant activity in several rodent models, including lipopolysaccharide (LPS)-induced depression. In this study we tested the ability of IGF-I and GPE (the N-terminal tri-peptide derived from IGF-I) to alter depression-like behavior induced by intraperitoneal (i.p.) administration of LPS in a preventive and curative manner. In the first case, IGF-I (1 μg) or GPE (5 μg) was administered i.c.v. to CD-1 mice followed 30 min later by 330 μg/kg body weight i.p. LPS. In the second case, 830 μg/kg body weight LPS was given 24 h prior to either IGF-I or GPE. When administered i.p., LPS induced full-blown sickness assessed as a loss of body weight, decrease in food intake and sickness behavior. None of these indices were affected by IGF-I or GPE. LPS also induced depression-like behavior; assessed as an increased duration of immobility in the tail suspension and forced swim tests. When administered before or after LPS, IGF-I and GPE abrogated the LPS response; attenuating induction of depression-like behaviors and blocking preexistent depression-like behaviors. Similar to previous work with IGF-I, GPE decreased brain expression of cytokines in response to LPS although unlike IGF-I, GPE did not induce the expression of brain-derived neurotrophic factor (BDNF). LPS induced expression of tryptophan dioxygenases, IDO1, IDO2 and TDO2, but expression of these enzymes was not altered by GPE. Thus, both IGF-I and GPE elicit specific improvement in depression-like behavior independent of sickness, an action that could be due to their anti-inflammatory properties. |
| تدمد: | 1742-2094 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870acdf0721155cebef97c6eadc37fa2Test https://doi.org/10.1186/1742-2094-8-179Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....870acdf0721155cebef97c6eadc37fa2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17422094 |
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