Effect of temperature-sensitive nanogel combined with angioplasty on sICAM-1 and VE-cadherin in lower extremity arterial occlusion rabbits
| العنوان: | Effect of temperature-sensitive nanogel combined with angioplasty on sICAM-1 and VE-cadherin in lower extremity arterial occlusion rabbits |
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| المؤلفون: | Ming Qi, Ze Song, Lei Wang, Xu Xie |
| المصدر: | Bioengineered, Vol 12, Iss 2, Pp 12535-12543 (2021) Bioengineered article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Nanogels, Bioengineering, Arterial Occlusive Diseases, Applied Microbiology and Biotechnology, Antigens, CD, Cell Line, Tumor, Animals, Humans, subintimal angioplasty, lower extremity arterial occlusion, Cell Proliferation, Angioplasty, Temperature, temperature-sensitive nanogel, General Medicine, Cadherins, Intercellular Adhesion Molecule-1, Survival Rate, Lower Extremity, vascular embolization agent, Rabbits, TP248.13-248.65, HeLa Cells, Research Article, Research Paper, Biotechnology |
| الوصف: | The study was to explore the effect of subintimal angioplasty (SIA) on the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular endothelial cadherin (VE-cadherin) in the rabbit model of lower extremity arterial occlusion. Specifically, the poly(N-isopropylacrylamide-co-butyl methacrylate) (PIB) temperature-sensitive nanogel was prepared, and the cytotoxicity of direct and indirect contact with PIB temperature-sensitive gel was analyzed then. Subsequently, the PIB temperature-sensitive gel was injected to the New Zealand white rabbit to prepare the lower extremity arterial occlusion model. The healthy control, model group, and SIA group were compared for the serum lipids, fibrinogen (Fbg), fibrinogen (Fbg), and fibrinogen (Fbg) levels. The results showed that the cell proliferation activity and survival rate were always higher than 90% under different concentrations of PIB temperature-sensitive gels. Compared with the model group, the SIA group had increased total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and Fbg levels, but decreased high-density lipoprotein (HDL) level (P |
| اللغة: | English |
| تدمد: | 2165-5987 2165-5979 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868755248f0641a71968e8e6710e1f83Test https://doaj.org/article/099fc8c86f794ed3a0ea3630f9e948a2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....868755248f0641a71968e8e6710e1f83 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21655987 21655979 |
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