NK Cells in Autoimmune Diseases: Protective or Pathogenic?
| العنوان: | NK Cells in Autoimmune Diseases: Protective or Pathogenic? |
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| المؤلفون: | Cai Zhang, Shujuan Liang, Meifang Liu |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Immunologic diseases. Allergy, immune tolerance, Immunology, Autoimmunity, Disease, Review, NK cells, NK subsets, medicine.disease_cause, Immune tolerance, Autoimmune Diseases, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunology and Allergy, Medicine, Animals, Humans, Innate immune system, business.industry, Type i diabetes mellitus, Killer Cells, Natural, 030104 developmental biology, Phenotype, Self Tolerance, local microenvironment, Cellular Microenvironment, T cell subset, Cytokines, business, lcsh:RC581-607, Autoantibody production, 030215 immunology |
| الوصف: | Autoimmune diseases generally result from the loss of self-tolerance (i.e., failure of the immune system to distinguish self from non-self), and are characterized by autoantibody production and hyperactivation of T cells, which leads to damage of specific or multiple organs. Thus, autoimmune diseases can be classified as organ-specific or systemic. Genetic and environmental factors contribute to the development of autoimmunity. Recent studies have demonstrated the contribution of innate immunity to the onset of autoimmune diseases. Natural killer (NK) cells, which are key components of the innate immune system, have been implicated in the development of multiple autoimmune diseases such as systemic lupus erythematosus, type I diabetes mellitus, and autoimmune liver disease. However, NK cells have both protective and pathogenic roles in autoimmunity depending on the NK cell subset, microenvironment, and disease type or stage. In this work, we review the current knowledge of the varied roles of NK cell subsets in systemic and organic-specific autoimmune diseases and their clinical potential as therapeutic targets. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8651c3f13d7a9d3ba2ebc4845a58481dTest http://europepmc.org/articles/PMC7994264Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8651c3f13d7a9d3ba2ebc4845a58481d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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