Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
| العنوان: | Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease |
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| المؤلفون: | Mark Trentalange, Huiping Dong, Akiko Iwasaki, Kimberly Martinod, Michal Caspi Tal, Albert C. Shaw, Ryan D. Molony, Richard A. Flavell, Angel G. Solis, Peter Staeheli, Robert J. Homer, Denisa D. Wagner, Ruth R. Montgomery, Piotr Bielecki, Subhasis Mohanty, Iris K. Pang, Padmini S. Pillai |
| المصدر: | Science. 352:463-466 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, Myxovirus Resistance Proteins, 0301 basic medicine, Neutrophils, Context (language use), Disease, Biology, medicine.disease_cause, Article, Monocytes, Mice, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Orthomyxoviridae Infections, Immunity, Influenza, Human, medicine, Influenza A virus, Animals, Humans, Respiratory Tract Infections, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, Membrane Glycoproteins, Multidisciplinary, Effector, Caspase 1, Inflammasome, Bacterial Infections, Interferon-beta, TLR7, Viral Load, Virology, Caspases, Initiator, Immunity, Innate, 030104 developmental biology, Toll-Like Receptor 7, Caspases, Immunology, Female, Viral load, 030215 immunology, medicine.drug |
| الوصف: | Flu immunity shows its age As we age, our immune systems change; in many ways not for the better. For instance, the elderly account for 90% of influenza deaths annually. Pillai et al. now report that influenza-infected human monocytes, a type of immune cell, exhibit reduced antiviral activity. In influenza-infected mice, two innate immune sensing pathways work together to promote antiviral immunity to influenza. Mice lacking antiviral immunity (similar to the situation in elderly people) had elevated bacterial burdens in their lungs and increased inflammatory responses, which both contributed to their increased susceptibility to influenza. Science , this issue p. 463 |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856587a398437861ba873b320e970257Test https://doi.org/10.1126/science.aaf3926Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....856587a398437861ba873b320e970257 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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