Association of Dll4/Notch and HIF-1a -VEGF Signaling in the Angiogenesis of Missed Abortion
| العنوان: | Association of Dll4/Notch and HIF-1a -VEGF Signaling in the Angiogenesis of Missed Abortion |
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| المؤلفون: | Chunyan Ji, Yan Fang, Beihua Kong, Ping Sun, Daoxin Ma, Yuyan Ma, Shuang Yu |
| المصدر: | PLoS ONE PLoS ONE, Vol 8, Iss 8, p e70667 (2013) |
| بيانات النشر: | Public Library of Science, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Oncology, Vascular Endothelial Growth Factor A, Anatomy and Physiology, Angiogenesis, Epidemiology, lcsh:Medicine, Gene Expression, Abortion, Biochemistry, Pregnancy, Molecular Cell Biology, lcsh:Science, Hypoxia, reproductive and urinary physiology, Multidisciplinary, Neovascularization, Pathologic, Obstetrics and Gynecology, Vascular endothelial growth factor A, medicine.anatomical_structure, embryonic structures, cardiovascular system, Chorionic villi, Medicine, Intercellular Signaling Peptides and Proteins, Female, Abortion, Missed, Chorionic Villi, Research Article, Signal Transduction, Adult, medicine.medical_specialty, Cell signaling, Adolescent, Clinical Research Design, Notch signaling pathway, Endocrine System, Molecular Genetics, Internal medicine, Growth Factors, medicine, Genetics, Humans, Management of High-Risk Pregnancies, Biology, Fetal Death, Adaptor Proteins, Signal Transducing, Endocrine Physiology, Population Biology, business.industry, lcsh:R, Calcium-Binding Proteins, Case-control study, Proteins, Computational Biology, Abortion, Induced, medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Endocrinology, Gene Expression Regulation, Case-Control Studies, lcsh:Q, business |
| الوصف: | Background Dll4/Notch and HIF-1a-VEGF have been shown to play an important role during angiogenesis, but there are no data about their roles and association in missed abortion. In this study, we investigated the association of Dll4/Notch and HIF-1a-VEGF signaling in missed abortion. Methods Women with missed abortion (n = 27) and healthy controls (n = 26) were included in the study. Real-time Reverse Transcription-PCR Analyses (RT-PCR) was used to analyze the mRNA levels of Dll4/Notch and HIF-1a-VEGF signaling molecules. The protein level for Dll4 was measured by immunohistochemistry. Results Compared with induced abortion, the expression of VEGF was statistically reduced while the level of VEGFR1 and Notch1 was significantly up-regulated in missed abortion. Though other molecules (VEGFR2 and Dll4) were marginally higher in missed abortion, no statistical difference was observed. The expression of HIF-1a was significantly up-regulated, and close negatively correlated with VEGF in missed abortion. Both in induced abortion and missed abortion, Dll4 was positively correlated with Notch1. Conclusions The early pregnancy is in a hypoxic environment, this may encourage the angiogenesis, but severe hypoxic may inhibit the angiogenesis. Aberrant Dll4/Notch and HIF-1a-VEGF signaling may have a role in missed abortion. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8536478d796439b058eea87bb752934fTest http://europepmc.org/articles/PMC3739820Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8536478d796439b058eea87bb752934f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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