Comparison of Glomerular Filtration Rate Estimation from Serum Creatinine and Cystatin C in HNF1A-MODY and Other Types of Diabetes
| العنوان: | Comparison of Glomerular Filtration Rate Estimation from Serum Creatinine and Cystatin C in HNF1A-MODY and Other Types of Diabetes |
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| المؤلفون: | Tomasz Klupa, Maciej T. Malecki, Teresa Koblik, Maria Kapusta, Bartłomiej Matejko, Maciej Borowiec, Beata Kieć-Wilk, Magdalena Szopa |
| المصدر: | Journal of Diabetes Research, Vol 2015 (2015) Journal of Diabetes Research |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Article Subject, Endocrinology, Diabetes and Metabolism, Renal function, Type 2 diabetes, Kidney Function Tests, urologic and male genital diseases, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Cohort Studies, Young Adult, chemistry.chemical_compound, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Humans, Clinical significance, Hepatocyte Nuclear Factor 1-alpha, Cystatin C, Type 1 diabetes, Creatinine, lcsh:RC648-665, biology, business.industry, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, chemistry, biology.protein, Female, Poland, Cystatin, business, Glomerular Filtration Rate, Research Article |
| الوصف: | Introduction. We previously showed that in HNF1A-MODY the cystatin C-based glomerular filtration rate (GFR) estimate is higher than the creatinine-based estimate. Currently, we aimed to replicate this finding and verify its clinical significance. Methods. The study included 72 patients with HNF1A-MODY, 72 with GCK-MODY, 53 with type 1 diabetes (T1DM), 70 with type 2 diabetes (T2DM), and 65 controls. Serum creatinine and cystatin C levels were measured. GFR was calculated from creatinine and cystatin C using the CKD-EPI creatinine equation (eGRF-cr) and CKD-EPI cystatin C equation (eGFR-cys), respectively. Results. Cystatin C levels were lower (p<0.001) in the control (0.70±0.13 mg/L), HNF1A (0.75±0.21), and GCK (0.72±0.16 mg/L) groups in comparison to those with either T1DM (0.87±0.15 mg/L) or T2DM (0.9±0.23 mg/L). Moreover, eGFR-cys was higher than eGRF-cr in HNF1A-MODY, GCK-MODY, and the controls (p=0.004; p=0.003; p<0.0001). This corresponded to 8.9 mL/min/1.73 m2, 9.7 mL/min/1.73 m2, and 16.9 mL/min/1.73 m2 of difference. Additionally, T1DM patients had higher eGFR-cr than eGFR-cys (11.6 mL/min/1.73 m2; p=0.0004); no difference occurred in T2DM (p=0.91). Conclusions. We confirmed that eGFR-cys values in HNF1A-MODY patients are higher compared to eGFR-cr. Some other differences were also described in diabetic groups. However, none of them appears to be clinically relevant. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6753 2314-6745 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848ab903eedd1d5bb640d865c59ca53dTest https://doaj.org/article/9a3714b4823548f8ae758186f9cf67a7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....848ab903eedd1d5bb640d865c59ca53d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146753 23146745 |
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