Persistent effects of the orexin-1 receptor antagonist SB-334867 on naloxone precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine dependent rats
| العنوان: | Persistent effects of the orexin-1 receptor antagonist SB-334867 on naloxone precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine dependent rats |
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| المؤلفون: | Mostafa Lavaie, Alireza Komaki, Masoumeh Gholami, Mohammad Taghi Joghataei, Masoumeh Kourosh-Arami, Zohreh Najafi |
| المصدر: | International Journal of Neuroscience. 132:67-76 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Narcotics, 0301 basic medicine, medicine.drug_class, Narcotic Antagonists, (+)-Naloxone, Pharmacology, Nociceptive Pain, 03 medical and health sciences, 0302 clinical medicine, SB-334867, Animals, Urea, Medicine, Naphthyridines, Rats, Wistar, Benzoxazoles, Behavior, Animal, Morphine, Naloxone, business.industry, General Neuroscience, Antagonist, General Medicine, Receptor antagonist, Rats, Substance Withdrawal Syndrome, Blockade, Orexin, Disease Models, Animal, 030104 developmental biology, Nociception, Orexin Receptor Antagonists, business, Morphine Dependence, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Aim of the study In this study, we investigated the effect of long-term administration of orexin receptor 1 (OXR1) antagonist on naloxone-precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine-dependent rats. Materials and methods Wistar rats received subcutaneous (s.c.) injections of morphine (6, 16, 26, 36, 46, 56, and 66 mg/kg, 2 ml/kg) at an interval of 24 h for 7 days. In chronic groups, the OXR1 antagonist, SB-334867 (20 mg/kg, i.p.), or its vehicle, was injected repetitively from postnatal day 1 (PND1)-PND23 and then for the following seven days before each morphine injection. Meanwhile, in acute groups, SB-334867, or its vehicle, was administered before each morphine injection. In groups of rats that were designated for withdrawal experiments, naloxone (2.5 mg/kg, i.p.) was administered after the last injection of morphine. In the formalin-induced pain, the effect of OXR1 inhibition on the antinociceptive effects of morphine was measured by injecting formalin after the final morphine injection. Results Animals that received long-term SB-334867 administration before morphine injection demonstrated a significant reduction in chewing, defecation, diarrhea, grooming, teeth chattering, wet-dog shake, and writhing. Inhibiting OXR1 for a long time increased formalin-induced nociceptive behaviors in interphase and phase II of the formalin-induced pain. Conclusions Our results indicated that the inhibition of OXR1 significantly reduces the development of morphine dependence and behavioral signs elicited by the administration of naloxone in morphine-dependent rats. Furthermore, the prolonged blockade of OXR1 might be involved in formalin-induced nociceptive behaviors. |
| تدمد: | 1543-5245 0020-7454 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844c4f26276b4eea3e3af400fd7eee19Test https://doi.org/10.1080/00207454.2020.1802266Test |
| رقم الانضمام: | edsair.doi.dedup.....844c4f26276b4eea3e3af400fd7eee19 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15435245 00207454 |
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