Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
| العنوان: | Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel |
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| المؤلفون: | Raffaella Buzzetti, Zhiguang Zhou, Tiinamaija Tuomi, Massimo Pietropaolo, Richard David Leslie, Paolo Pozzilli, Didac Mauricio |
| المساهمون: | Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institute for Molecular Medicine Finland, Research Programs Unit, CAMM - Research Program for Clinical and Molecular Metabolism, University of Helsinki |
| المصدر: | DIABETES r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau) r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Diabetes |
| بيانات النشر: | AMER DIABETES ASSOC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Latent autoimmune diabetes of adults, Male, Endotype, Endocrinology, Diabetes and Metabolism, Consensus Development Conferences as Topic, International Cooperation, LADA CHINA, Type 2 diabetes, METABOLIC-CONTROL, LADA, law.invention, 0302 clinical medicine, Randomized controlled trial, law, C-Peptide, Glutamate Decarboxylase, C-PEPTIDE SECRETION, Middle Aged, 3. Good health, Practice Guidelines as Topic, Female, GENE VARIANTS, Algorithms, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, INSULIN REQUIREMENT, 03 medical and health sciences, Therapeutic approach, GLUTAMIC-ACID DECARBOXYLASE, BETA-CELL FUNCTION, Diabetes mellitus, Internal medicine, therapeutic approach, C-peptide, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Genetic Predisposition to Disease, Latent Autoimmune Diabetes in Adults, TYPE-1, Aged, Type 1 diabetes, business.industry, medicine.disease, Clinical trial, 030104 developmental biology, Sulfonylurea Compounds, Diabetes Mellitus, Type 2, 3121 General medicine, internal medicine and other clinical medicine, ONSET, Perspectives in Diabetes, AUTOANTIBODIES, business |
| الوصف: | A substantial proportion of patients with adult-onset diabetes share features of both type 1 diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically resemble T2D patients by not requiring insulin treatment, yet they have immunogenetic markers associated with T1D. Such a slowly evolving form of autoimmune diabetes, described as latent autoimmune diabetes of adults (LADA), accounts for 2–12% of all patients with adult-onset diabetes, though they show considerable variability according to their demographics and mode of ascertainment. While therapeutic strategies aim for metabolic control and preservation of residual insulin secretory capacity, endotype heterogeneity within LADA implies a personalized approach to treatment. Faced with a paucity of large-scale clinical trials in LADA, an expert panel reviewed data and delineated one therapeutic approach. Building on the 2020 American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD) consensus for T2D and heterogeneity within autoimmune diabetes, we propose “deviations” for LADA from those guidelines. Within LADA, C-peptide values, proxy for β-cell function, drive therapeutic decisions. Three broad categories of random C-peptide levels were introduced by the panel: 1) C-peptide levels 0.7 nmol/L: suggests a modified ADA/EASD algorithm as for T2D but allowing for the potentially progressive nature of LADA by monitoring C-peptide to adjust treatment. The panel concluded by advising general screening for LADA in newly diagnosed non–insulin-requiring diabetes and, importantly, that large randomized clinical trials are warranted. |
| تدمد: | 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842e03667c43dd14d7373fcb0eafcf1cTest https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1350Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....842e03667c43dd14d7373fcb0eafcf1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00121797 |
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