Genetic Polymorphisms of Cytochrome P450 Enzymes and Transport Proteins in a Russian Population and Three Ethnic Groups of Dagestan
| العنوان: | Genetic Polymorphisms of Cytochrome P450 Enzymes and Transport Proteins in a Russian Population and Three Ethnic Groups of Dagestan |
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| المؤلفون: | Dmitry A. Sychev, G. N. Shuev, Kristina A Ryzhikova, Daniyal Musaevich Gafurov, K. B. Mirzaev, Zhannet A Sozaeva, Suleiman Nurattinovich Mammaev, Elena A. Grishina, Olga D. Konova |
| المصدر: | Genetic Testing and Molecular Biomarkers. 21:747-753 |
| بيانات النشر: | Mary Ann Liebert Inc, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, ATP Binding Cassette Transporter, Subfamily B, Genotype, Ethnic group, Biology, Real-Time Polymerase Chain Reaction, White People, Russia, 03 medical and health sciences, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Gene Frequency, Dagestan, Ethnicity, Humans, Allele, Genotyping, Allele frequency, Alleles, Genetics (clinical), Cytochrome P-450 CYP2C9, Genetics, Polymorphism, Genetic, Liver-Specific Organic Anion Transporter 1, General Medicine, Healthy Volunteers, Cytochrome P-450 CYP2C19, 030104 developmental biology, Cytochrome P-450 CYP2D6, Genetic marker, 030220 oncology & carcinogenesis, biology.protein, Female, Carrier Proteins, SLCO1B1, Pharmacogenetics |
| الوصف: | Aim: The objective of this study was to investigate the prevalence of polymorphic markers of the CYP2C19, CYP2C9, CYP2D6, SLCO1B1, and ABCB1 genes among the three ethnic groups in Dagestan and compare it with the carrier frequency of these markers among the Russian population living in Moscow. Methods: The study involved 186 healthy, unrelated, and chronic medication-free volunteers (53 males and 133 females) of the three ethnic groups in the Dagestan Republic: 46 Laks, 90 Avars, and 50 Dargins. Genotyping was performed using real-time polymerase chain reaction-based methods. The allelic prevalences of the three Dagestan peoples were compared with ethnic Russians from the Moscow region. Results: Statistically significant differences for the following gene polymorphisms: CYP2C19*17, CYP2C9*3, ABCB1 (C3435T), SLCO1B1*5 were found between the Russian population and the three ethnic groups of the Dagestan republic. Conclusion: The data obtained from this study will help with prioritization genotyping in the r... |
| تدمد: | 1945-0257 1945-0265 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8403bd2fef4ca6dc48a59a5bf32746ceTest https://doi.org/10.1089/gtmb.2017.0036Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8403bd2fef4ca6dc48a59a5bf32746ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19450257 19450265 |
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