Metabolic control and complications over 3 years in patients with insulin dependent diabetes (IDDM): the Stockholm Diabetes Intervention Study (SDIS)
| العنوان: | Metabolic control and complications over 3 years in patients with insulin dependent diabetes (IDDM): the Stockholm Diabetes Intervention Study (SDIS) |
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| المؤلفون: | P. Reichard, B. Y. Nilsson, P. Carlsson, Urban Rosenqvist, I. Cars, A. Britz, L. Lindblad |
| المصدر: | Journal of Internal Medicine. 228:511-517 |
| بيانات النشر: | Wiley, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Adult, Blood Glucose, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Weight Gain, Gastroenterology, Drug Administration Schedule, Nephropathy, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Insulin, Glycated Hemoglobin, Diabetic Retinopathy, business.industry, Microangiopathy, medicine.disease, Confidence interval, Surgery, Diabetes Mellitus, Type 1, Metabolic control analysis, business, Complication, Retinopathy |
| الوصف: | In a planned 5-year study, 97 patients with insulin dependent diabetes mellitus (IDDM), non-proliferative retinopathy and unsatisfactory blood glucose control were monitored for 3 years. The patients were randomized to an intensified conventional treatment (ICT, n = 44) or a regular treatment (RT, n = 53) group. HbA1c (normal range 3.9-5.7%) was reduced from 9.5 +/- 0.2 (mean value +/- SEM) to 7.4 +/- 0.1% in the ICT group (P = 0.0001), and from 9.5 +/- 0.2 to 9.0 +/- 0.2% in the RT group (P = 0.004). Nerve conduction velocities in the sural and peroneal nerves (P = 0.01-0.0001) were impaired in the RT group, but not in the ICT group. Retinopathy increased in both groups. The condition of 22 ICT patients (50%, 95% confidence interval 34-66%) and 37 RT patients (73%, 61-84%) deteriorated with regard to at least one microvascular complication (retinopathy, nephropathy, neuropathy) (P = 0.024). Lower HbA1c levels during the study significantly reduced the risk of deterioration (P = 0.01). In total, 57% of the ICT patients had at least one episode of serious hypoglycaemia, compared with 23% in the RT group (P = 0.001). The patients in the ICT group also gained weight (P = 0.0001). Improved blood glucose control slowed down the progression of microangiopathy during a 3-year period in patients with non-proliferative retinopathy, but at the price of an increased frequency of serious hypoglycaemic episodes, and some gain in body weight. |
| تدمد: | 1365-2796 0954-6820 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e829139d7456cec9028e5e3afd227cTest https://doi.org/10.1111/j.1365-2796.1990.tb00271.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....83e829139d7456cec9028e5e3afd227c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652796 09546820 |
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