Gut Microbes and Hepatic Encephalopathy: From the Old Concepts to New Perspectives
| العنوان: | Gut Microbes and Hepatic Encephalopathy: From the Old Concepts to New Perspectives |
|---|---|
| المؤلفون: | Alba Rocco, C. Sgamato, Pietro Coccoli, Olga Maria Nardone, Debora Compare, Gerardo Nardone |
| المساهمون: | Rocco, A., Sgamato, C., Compare, D., Coccoli, P., Nardone, O. M., Nardone, G. |
| المصدر: | Frontiers in Cell and Developmental Biology, Vol 9 (2021) Frontiers in Cell and Developmental Biology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, QH301-705.5, hepatic encephalopathy, Review, Gut flora, gut microbe, gut-liver-brain axi, antibiotics, Pathogenesis, Cell and Developmental Biology, Liver disease, Lethargy, antibiotic, medicine, Biology (General), Intensive care medicine, Hepatic encephalopathy, Severe complication, biology, business.industry, Liver failure, fecal microbiota transplantation, Cell Biology, medicine.disease, Research findings, biology.organism_classification, gut-liver-brain axis, gut microbes, probiotics, business, Developmental Biology |
| الوصف: | Hepatic encephalopathy (HE) is a severe complication of advanced liver disease and acute liver failure. The clinical spectrum ranges from minor cognitive dysfunctions to lethargy, depressed consciousness, and coma and significantly impact the quality of life, morbidity, and mortality of the patients. It is commonly accepted that the gut milieu is essential for the development of HE; however, despite intensive research efforts, the pathogenesis of HE is still not fully elucidated. As our knowledge of gut microbiota moves from the pioneering era of culture-dependent studies, the connection between microbes, inflammation, and metabolic pathways in the pathogenesis of HE is becoming increasingly clear, providing exciting therapeutic perspectives. This review will critically examine the latest research findings on the role of gut microbes in the pathophysiological pathways underlying HE. Moreover, currently available therapeutic options and novel treatment strategies are discussed. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e5232e750bbd8cad3968ad5526a161Test https://www.frontiersin.org/articles/10.3389/fcell.2021.748253/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....83e5232e750bbd8cad3968ad5526a161 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |