Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity
| العنوان: | Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity |
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| المؤلفون: | Hanna-Mari Takkinen, Iris Erlund, Suvi Ahonen, Outi Vaarala, Mikael Knip, Jorma Toppari, Jorma Ilonen, Sari Niinistö, Suvi M. Virtanen, Riitta Veijola |
| المساهمون: | Clinicum, Mikael Knip / Principal Investigator, Children's Hospital, Lastentautien yksikkö, Diabetes and Obesity Research Program, Research Programs Unit, HUS Children and Adolescents |
| المصدر: | Diabetologia. 60:1223-1233 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, CHILDHOOD, Autoimmunity, Fatty acid status, medicine.disease_cause, SERUM, Cohort Studies, COWS MILK CONSUMPTION, chemistry.chemical_compound, 0302 clinical medicine, HLA-DQ beta-Chains, Palmitoleic acid, 030212 general & internal medicine, Finland, 2. Zero hunger, chemistry.chemical_classification, Fatty Acids, HLA-CONFERRED SUSCEPTIBILITY, COD-LIVER OIL, n-3 fatty acids, 3. Good health, Type 1 diabetes, Milk, Treatment Outcome, Docosahexaenoic acid, Child, Preschool, Female, Risk, YOUNG-CHILDREN, medicine.medical_specialty, Breast milk, Chromatography, Gas, Genotype, 030209 endocrinology & metabolism, Islets of Langerhans, 03 medical and health sciences, Internal medicine, Fatty Acids, Omega-3, Internal Medicine, medicine, Animals, Humans, Genetic Predisposition to Disease, ISLET AUTOIMMUNITY, DISEASE-ASSOCIATED AUTOANTIBODIES, Autoantibodies, Milk, Human, business.industry, Insulin, Infant, Newborn, Autoantibody, Infant, Fatty acid, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, chemistry, 3121 General medicine, internal medicine and other clinical medicine, Case-Control Studies, ANTIBODIES, BETA-CELL AUTOIMMUNITY, business |
| الوصف: | Aims/hypothesis We investigated the association of early serum fatty acid composition with the risk of type 1 diabetes-associated autoimmunity. Our hypothesis was that fatty acid status during infancy is related to type 1 diabetes-associated autoimmunity and that long-chain n-3 fatty acids, in particular, are associated with decreased risk. Methods We performed a nested case-control analysis within the Finnish Type 1 Diabetes Prediction and Prevention Study birth cohort, carrying HLA-conferred susceptibility to type 1 diabetes (n = 7782). Serum total fatty acid composition was analysed by gas chromatography in 240 infants with islet autoimmunity and 480 control infants at the age of 3 and 6 months. Islet autoimmunity was defined as repeated positivity for islet cell autoantibodies in combination with at least one of three selected autoantibodies. In addition, a subset of 43 infants with primary insulin autoimmunity (i.e. those with insulin autoantibodies as the first autoantibody with no concomitant other autoantibodies) and a control group (n = 86) were analysed. A third endpoint was primary GAD autoimmunity defined as GAD autoantibody appearing as the first antibody without other concomitant autoantibodies (22 infants with GAD autoimmunity; 42 infants in control group). Conditional logistic regression was applied, considering multiple comparisons by false discovery rate |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835e301d400a371ddfd0fd656e095713Test https://doi.org/10.1007/s00125-017-4280-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....835e301d400a371ddfd0fd656e095713 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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