Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate
| العنوان: | Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate |
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| المؤلفون: | Karl J. A. McCullagh, George J. F. Heigenhauser, E. Hultman, Norman L. Jones, Arend Bonen, Charles T. Putman |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 274:E102-E107 |
| بيانات النشر: | American Physiological Society, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Male, Monocarboxylic Acid Transporters, medicine.medical_specialty, Time Factors, Physiology, Endocrinology, Diabetes and Metabolism, Physical exercise, Femoral artery, Oxygen Consumption, Physiology (medical), medicine.artery, Internal medicine, medicine, Humans, Exercise physiology, Muscle, Skeletal, Exercise, Muscle biopsy, medicine.diagnostic_test, biology, business.industry, Membrane Proteins, VO2 max, Skeletal muscle, Venous blood, Femoral Vein, Femoral Artery, Endocrinology, Monocarboxylate transporter 1, medicine.anatomical_structure, Exercise Test, Lactates, Physical Endurance, biology.protein, Carrier Proteins, business, Glycogen |
| الوصف: | We examined the effects of increasing a known lactate transporter protein, monocarboxylate transporter 1 (MCT1), on lactate extrusion from human skeletal muscle during exercise. Before and after short-term bicycle ergometry training [2 h/day, 7 days at 65% maximal oxygen consumption (V˙o 2 max)], subjects ( n = 7) completed a continuous bicycle ergometer ride at 30%V˙o 2 max (15 min), 60%V˙o 2 max (15 min), and 75% V˙o 2 max (15 min). Muscle biopsy samples (vastus lateralis) and arterial and femoral venous blood samples were obtained before exercise and at the end of each workload. After 7 days of training the MCT1 content in muscle was increased (+18%; P < 0.05). The concentrations of both muscle lactate and femoral venous lactate were reduced during exercise ( P < 0.05) that was performed after training. High correlations were observed between muscle lactate and venous lactate before training ( r = 0.92, P < 0.05) and after training ( r = 0.85, P < 0.05), but the slopes of the regression lines between these variables differed markedly. Before training, the slope was 0.12 ± 0.01 mM lactate ⋅ mmol lactate−1 ⋅ kg muscle dry wt−1, and this was increased by 33% after training to 0.18 ± 0.02 mM lactate ⋅ mmol lactate−1 ⋅ kg muscle dry wt−1. This indicated that after training the femoral venous lactate concentrations were increased for a given amount of muscle lactate. These results suggest that lactate extrusion from exercising muscles is increased after training, and this may be associated with the increase in skeletal muscle MCT1. |
| تدمد: | 1522-1555 0193-1849 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8358095b644c4b40617420dcc311de71Test https://doi.org/10.1152/ajpendo.1998.274.1.e102Test |
| رقم الانضمام: | edsair.doi.dedup.....8358095b644c4b40617420dcc311de71 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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