Updates in Novel Therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
| العنوان: | Updates in Novel Therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) |
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| المؤلفون: | Naveen Pemmaraju, David A. Rizzieri, Minas P. Economides |
| المصدر: | Current Hematologic Malignancy Reports. 14:515-522 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Clinical Decision-Making, Disease, Clonal Evolution, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, medicine, Humans, Molecular Targeted Therapy, Adverse effect, Hematology, Venetoclax, business.industry, Disease Management, Dendritic Cells, medicine.disease, Combined Modality Therapy, Transplantation, Clinical trial, Leukemia, Treatment Outcome, medicine.anatomical_structure, chemistry, Hematologic Neoplasms, 030220 oncology & carcinogenesis, Disease Susceptibility, Bone marrow, business, 030215 immunology |
| الوصف: | Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, clinically aggressive hematologic malignancy that has heterogeneous presentation and can involve the skin, lymph nodes, and bone marrow. Recent advancements in our patho-biologic understanding of the disease have led to the development of new targeted therapies for BPDCN. In this review, we aimed to describe some of the novel treatments that are being put forward for the management of BPDCN. Tagraxofusp is the first CD123-targeted therapy approved as the first ever targeted treatment of BPDCN in patients aged 2 years and older. This agent was approved based on a pivotal clinical trial that showed that it was associated with high rates of clinical responses in both treatment-naive and treatment-experienced patients. The most serious adverse event was occurrence of the capillary leak syndrome. Other targeted therapies are actively being investigated in clinical trials. These include other CD123-targeted approaches, as well as active investigation in targets beyond CD123, such as the BCL-2 inhibitor, venetoclax. BPDCN is a rare hematologic clonal disorder with historically poor outcomes. Newer targeted therapies have been recently introduced, with promising results and novel toxicities that are important to recognize and understand. Stem cell transplantation after achievement of complete remission remains the mainstay of therapy among younger/fit, eligible patients, regardless of treatment modality used. |
| تدمد: | 1558-822X 1558-8211 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83157e1c1e61936eefbc3c1eca4ccf39Test https://doi.org/10.1007/s11899-019-00556-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....83157e1c1e61936eefbc3c1eca4ccf39 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1558822X 15588211 |
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