FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia
| العنوان: | FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia |
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| المؤلفون: | Shouluan Ding, Jicun Pan, Elena Kashentseva, Jiongru Wu, Randall S. Davis, Nicholas Chiorazzi, Yufeng Li, Mikhail A. Shakhmatov, Fu Jun Li, Seng-Jaw Soong |
| المصدر: | Blood. 112:179-187 |
| بيانات النشر: | American Society of Hematology, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Genes, Immunoglobulin Heavy Chain, Chronic lymphocytic leukemia, Concordance, Immunology, Gene Expression, Receptors, Cell Surface, Receptors, Fc, CD38, Biochemistry, CD19, Cohort Studies, immune system diseases, hemic and lymphatic diseases, Internal medicine, Biomarkers, Tumor, medicine, Humans, Receptors, Immunologic, Gene, Aged, Aged, 80 and over, B-Lymphocytes, Membrane Glycoproteins, ZAP-70 Protein-Tyrosine Kinase, Neoplasia, biology, hemic and immune systems, Cell Biology, Hematology, Middle Aged, Prognosis, medicine.disease, ADP-ribosyl Cyclase 1, Leukemia, Lymphocytic, Chronic, B-Cell, Case-Control Studies, Mutation, Mutation (genetic algorithm), biology.protein, Female, IGHV@, Clinical progression |
| الوصف: | CD38 and ZAP-70 are both useful prognostic markers for B-cell chronic lymphocytic leukemia (CLL), but are variably discordant with IGHV mutation status. A total of 5 human Fc receptor–like molecules (FCRL1-5) have tyrosine-based immunoregulatory potential and are expressed by B-lineage subpopulations. To determine their prognostic potential in CLL, FCRL expression was compared with IGHV mutation status, CD38 and ZAP-70 expression, and clinical features from 107 patients. FCRL1, FCRL2, FCRL3, and FCRL5 were found at markedly higher levels on CLL cells bearing mutated IGHV genes than on unmutated CLL cells or CD19+ polyclonal B lymphocytes. Univariate comparisons found that similar to CD38 and ZAP-70, FCRL expression was strongly associated with IGHV mutation status; however, only FCRL2 maintained independent predictive value by multivariate logistic analysis. Strikingly, FCRL2 demonstrated 94.4% concordance with IGHV mutation compared with 76.6% for CD38 and 80.4% for ZAP-70. Compared with other indicators, FCRL2 was also superior at predicting the time to first therapy; the median treatment-free interval was 15.5 years for patients with high FCRL2 expression compared with 3.75 years for FCRL2-low patients. Our studies indicate that FCRL2 has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in CLL. |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ae396054ff587dc5eb9d3912415b24Test https://doi.org/10.1182/blood-2008-01-131359Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....82ae396054ff587dc5eb9d3912415b24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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