Decreased β-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes
| العنوان: | Decreased β-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes |
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| المؤلفون: | Longyi Zeng, Yanhua Zhu, Hongrong Deng, Wen Xu, Jianping Weng, Xubin Yang, Ying Tan |
| المصدر: | Neuroscience Bulletin |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, β-cell function, Physiology, medicine.medical_treatment, Population, Cardiovascular autonomic neuropathy, Type 2 diabetes, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Asian People, Diabetic Neuropathies, Insulin-Secreting Cells, Internal medicine, Type 2 diabetes mellitus, medicine, Humans, Insulin, education, education.field_of_study, Autonomic nerve, business.industry, General Neuroscience, food and beverages, Type 2 Diabetes Mellitus, Fasting, General Medicine, Middle Aged, medicine.disease, Glucose, 030104 developmental biology, Postprandial, Diabetes Mellitus, Type 2, Original Article, Female, Insulin Resistance, business, Complication, 030217 neurology & neurosurgery, Homeostasis |
| الوصف: | The influence of β-cell function on cardiovascular autonomic neuropathy (CAN), an important diabetes-related complication, is still unclear. In this study, we aimed to investigate the association between residual β-cell function and CAN in patients newly diagnosed with type 2 diabetes. We enrolled 90 newly-diagnosed type 2 diabetic patients and 37 participants with normal glucose tolerance as controls. The patients were divided into a CAN+ group (diabetic patients with CAN, n = 20) and a CAN− group (diabetic patients without CAN, n = 70) according to the standard Ewing battery of tests. Fasting and postprandial plasma glucose, insulin, and C-peptide were measured. Homeostasis model assessment-beta cells (HOMA-B) and HOMA-insulin resistance (IR) were calculated. The prevalence of CAN in this population was 22.2%. Compared with the CAN− group, the CAN+ group had significantly lower fasting plasma insulin (6.60 ± 4.39 vs 10.45 ± 7.82 μ/L, P = 0.029), fasting C-peptide (0.51 ± 0.20 vs 0.82 ± 0.51 nmol/L, P = 0.004), and HOMA-B (21.44 ± 17.06 vs 44.17 ± 38.49, P = 0.002). Fasting C-peptide was correlated with the Valsalva ratio (r = 0.24, P = 0.043) and the 30:15 test (r = 0.26, P = 0.023). Further analysis showed that fasting C-peptide (OR: 0.041, 95% CI 0.003–0.501, P = 0.012) and HOMA-B (OR: 0.965, 95% CI 0.934–0.996, P = 0.028) were independently associated with cardiovascular autonomic nerve function in this population. The patients with fasting C-peptide values < 0.67 nmol/L were more likely to have CAN than those with C-peptide levels ≥0.67 nmol/L (OR: 6.00, 95% CI 1.815–19.830, P = 0.003). A high prevalence of CAN was found in patients with newly-diagnosed type 2 diabetes. Decreased β-cell function was closely associated with CAN in this population. |
| تدمد: | 1995-8218 1673-7067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ab59663586a44cea66e2db1a22b25eTest https://doi.org/10.1007/s12264-018-0304-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....82ab59663586a44cea66e2db1a22b25e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19958218 16737067 |
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