PET/CT with 18F-FDG–Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis
| العنوان: | PET/CT with 18F-FDG–Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis |
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| المؤلفون: | Pallab Ray, Niranjan Khandelwal, Naveen Kalra, Anish Bhattacharya, Rakesh Kochhar, Sarika Sharma, Bhagwant Rai Mittal |
| المصدر: | Journal of Nuclear Medicine. 55:1267-1272 |
| بيانات النشر: | Society of Nuclear Medicine, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Percutaneous, medicine.drug_class, medicine.medical_treatment, Antibiotics, Multimodal Imaging, Gastroenterology, Fluorodeoxyglucose F18, Laparotomy, Internal medicine, Leukocytes, medicine, Humans, Radiology, Nuclear Medicine and imaging, PET-CT, business.industry, Venous blood, medicine.disease, medicine.anatomical_structure, Pancreatitis, Isotope Labeling, Positron-Emission Tomography, Acute Disease, Absolute neutrophil count, Acute pancreatitis, Female, Radiology, Tomography, X-Ray Computed, Pancreas, business |
| الوصف: | Early detection of infection in acute pancreatitis (AP) affects the choice of treatment and clinical outcome. We used PET/CT with 18F-FDG–labeled autologous leukocytes to detect infection in pancreatic or peripancreatic fluid collections in patients with AP. Methods: Forty-one patients (28 men and 13 women) who were 21–69 y old (mean ± SD, 41 ± 11.5) and had AP and radiologic evidence of a fluid collection in or around the pancreas were studied. Leukocytes were separated from the patient’s venous blood, labeled with 18F-FDG, and reinjected intravenously; PET/CT images were acquired 2 h later. A final diagnosis of infection was based on microbiologic culture of fluid aspirated from the collection. Patients were treated with supportive care and antibiotics; percutaneous drainage or laparotomy was performed when indicated. Results: Blood glucose level, total leukocyte count, neutrophil count, and leukocyte labeling efficiency varied from 83 to 212 mg/100 mL (118 ± 30), 4,600 to 24,200/mm3 (11,648 ± 5,376), 55% to 90% (73 ± 10), and 31% to 97% (81 ± 17), respectively. Increased tracer uptake in the fluid collection was seen in 12 of 41 patients; 10 had culture-proven infection and underwent percutaneous drainage, and aspiration was unsuccessful in 2. The scan results were negative for infection in 29 patients; 25 had fluid culture results that were negative for infection, and aspiration was unsuccessful in 4. The sensitivity, specificity, and accuracy of the scan were all 100% in 35 patients for whom fluid culture reports were available. Conclusion: PET/CT with 18F-FDG–labeled leukocytes is a noninvasive and reliable method for the diagnosis of infection in pancreatic or peripancreatic fluid collections in patients with AP. |
| تدمد: | 2159-662X 0161-5505 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8228670e15fc7fcf537a562b9e8f62ecTest https://doi.org/10.2967/jnumed.114.137232Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8228670e15fc7fcf537a562b9e8f62ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2159662X 01615505 |
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