Cognitive and brain structural changes in long-term oligodendroglial tumor survivors
| العنوان: | Cognitive and brain structural changes in long-term oligodendroglial tumor survivors |
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| المؤلفون: | Francesc Graus, Miguel Gil-Gil, Noemi Vidal, Estela Camara, Marta Simó, Carles Majós, Jordi Bruna, Esteban Jaramillo-Jiménez, A. Lucas, Nuria Cayuela |
| المصدر: | Neuro Oncol |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Oligodendroglioma, Neuroimaging, Neuropsychological Tests, White matter, Leukoencephalopathy, Young Adult, Atrophy, Cancer Survivors, Internal medicine, medicine, Humans, Oligodendroglial Tumor, Longitudinal Studies, Gray Matter, Aged, Retrospective Studies, Cerebral atrophy, medicine.diagnostic_test, business.industry, Neuropsychology, Magnetic resonance imaging, Chemoradiotherapy, Middle Aged, Prognosis, medicine.disease, Magnetic Resonance Imaging, White Matter, Survival Rate, Cross-Sectional Studies, medicine.anatomical_structure, Female, Neurology (clinical), Cognition Disorders, business, Follow-Up Studies |
| الوصف: | Background We identify cognitive impairment and MRI structural brain changes in long-term oligodendroglial tumor survivors treated with radiation therapy (RT) alone (21%) or with chemotherapy (CT) (79%). Methods Oligodendroglial tumor patients (based on the World Health Organization [WHO] 2007 classification) who completed RT ± CT at least 2 years before the study initiation, were classified into 3 groups according to the time treatment was completed: Group 1 = 2–5 years (n = 22), Group 2 = 6–10 years (n = 13), and Group 3 >10 years (n = 13). All patients had a cross-sectional neuropsychological evaluation (n = 48) and a longitudinal volumetric analysis (gray matter [GM; n = 34]) between postsurgical and last follow-up MRI. White matter (WM) changes on MRI were assessed using a qualitative scale. Results There were no differences regarding tumor or treatment-related characteristics between groups. Six of 22 patients (27.3%) in Group 1; 5/13 (38.5%) in Group 2; and 9/13 (69.2%) in Group 3 had cognitive impairment that was considered severe in 3/22 patients (13.6%) in Group 1; 4/13 (30.8%) in Group 2; and 6/13 (46.2%) in Group 3. Patients in Groups 2 and 3 showed significant GM atrophy and more leukoencephalopathy than Group 1. Cognitive deficits were associated with brain atrophy and WM changes. Conclusions Long-term oligodendroglial tumor survivors who underwent standard RT ± CT treatment, mainly >5 years of its completion, present cognitive impairment, especially on memory and executive functions, associated with late GM and WM damage, thus highlighting the need of developing future strategies in patients with oligodendroglial tumor and long expected survival. |
| تدمد: | 1523-5866 1522-8517 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fc3055bf41899fa4bf113265d47770Test https://doi.org/10.1093/neuonc/noz130Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....81fc3055bf41899fa4bf113265d47770 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15235866 15228517 |
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