Poor prognosis in Epstein–Barr virus-negative gastric cancer with lymphoid stroma is associated with immune phenotype
| العنوان: | Poor prognosis in Epstein–Barr virus-negative gastric cancer with lymphoid stroma is associated with immune phenotype |
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| المؤلفون: | Hui Jeong Jeong, Jeong Hoon Lee, Young-Mi Park, Ho June Song, Sang-Yeob Kim, Seung-Jae Myung, Young Soo Park, Hyo Jeong Kang, Charles J. Cho, Hwoon-Yong Jung, Yeon-Mi Ryu, Hyun Lim |
| المصدر: | Gastric Cancer. 21:925-935 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Cancer Research, Pathology, medicine.medical_specialty, CD3 Complex, Lymphoid Tissue, CD3, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, medicine.disease_cause, B7-H1 Antigen, Pathogenesis, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Immune system, Stomach Neoplasms, Surgical oncology, Biomarkers, Tumor, Tumor Microenvironment, medicine, Humans, Aged, Retrospective Studies, biology, Tumor-infiltrating lymphocytes, business.industry, Gastroenterology, Cancer, General Medicine, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Epstein–Barr virus, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, biology.protein, Female, business, CD8 |
| الوصف: | Gastric cancer with lymphoid stroma (GCLS) is pathologically characterized by poorly developed tubular structures with a prominent lymphocytic infiltration. Its clinical and prognostic features differ in patients positive and negative for Epstein–Barr virus (EBV) infection. This study analyzed the expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and the density of tumor-infiltrating lymphocytes (TILs) including CD3+ and CD8+ T cells, as well as their prognostic significance in patients with GCLS. The study included 58 patients with GCLS (29 EBV+ and 29 EBV−) who underwent curative resection. Expression of CD3, CD8, PD-1, and PD-L1 in tumor cells and TILs was analyzed using a quantitative multispectral imaging system (Opal™), with these results validated by immuno-histochemical assays for PD-L1 on whole slide sections. The proportion of tumors overexpressing PD-L1 (31.0 vs. 0%, P = 0.002), TIL density (4548 vs. 2631/mm2, P |
| تدمد: | 1436-3305 1436-3291 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c44a782d301512b361b64bd574874cTest https://doi.org/10.1007/s10120-018-0820-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....81c44a782d301512b361b64bd574874c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14363305 14363291 |
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