Plasma Amyloid-β (Aβ42) Correlates with Cerebrospinal Fluid Aβ42 in Alzheimer's Disease
| العنوان: | Plasma Amyloid-β (Aβ42) Correlates with Cerebrospinal Fluid Aβ42 in Alzheimer's Disease |
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| المؤلفون: | Kaj Blennow, Henrik Zetterberg, Che-Chuan Yang, Charlotte E. Teunissen, Shieh-Yueh Yang, Ming-Jang Chiu, Philip Scheltens |
| المساهمون: | Amsterdam Neuroscience - Neurodegeneration, Laboratory Medicine, Neurology |
| المصدر: | Journal of Alzheimer's Disease, 62(4), 1857-1863. IOS Press Teunissen, C E, Chiu, M-J, Yang, C-C, Yang, S-Y, Scheltens, P, Zetterberg, H & Blennow, K 2018, ' Plasma Amyloid-β (Aβ42) Correlates with Cerebrospinal Fluid Aβ42 in Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 62, no. 4, pp. 1857-1863 . https://doi.org/10.3233/JAD-170784Test |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Amyloid β, Disease, Pathogenesis, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Alzheimer Disease, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, Amyloid beta-Peptides, business.industry, General Neuroscience, General Medicine, Middle Aged, University hospital, Peripheral blood, Peptide Fragments, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Endocrinology, Biomarker (medicine), Female, Geriatrics and Gerontology, Negative correlation, business, 030217 neurology & neurosurgery, Biomarkers |
| الوصف: | The 42 amino acid form of amyloid-β (Aβ42) plays a key role in the pathogenesis of Alzheimer's disease (AD) and is a core biomarker for the diagnosis of AD. Numerous studies have shown that cerebrospinal fluid (CSF) Aβ42 concentrations are decreased in AD, when measured by enzyme-linked immunosorbent assay (ELISA) and other conventional immunoassays. While most studies report no change in plasma Aβ42, independent studies using the immunomagnetic reduction (IMR) technique report an increase in plasma Aβ42 levels in AD. To confirm the opposite changes of Aβ42 levels in CSF and plasma for AD, we assayed the levels of Aβ42 in plasma of subjects with known CSF Aβ42 levels. In total 43 controls and 63 AD patients were selected at two sites: the VU University Medical Center (n = 55) and Sahlgrenska University Hospital (n = 51). IMR and ELISA were applied to assay Aβ42 in plasma and CSF, respectively. We found a moderately negative correlation between plasma and CSF Aβ42 levels in AD patients (r = -0.352), and a weakly positive correlation in controls (r = 0.186). These findings further corroborate that there are opposite changes of Aβ42 levels in CSF and plasma in AD. The possible causes for the negative correlation are discussed by taken assay technologies, Aβ42 transport from brain to peripheral blood, and sample matrix into account. |
| تدمد: | 1875-8908 1387-2877 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ef38c73a3985d2df05b0f23e8ea4e4Test https://pubmed.ncbi.nlm.nih.gov/29614646Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....80ef38c73a3985d2df05b0f23e8ea4e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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