Telomere length is a prognostic biomarker in elderly advanced ovarian cancer patients: a multicenter GINECO study
| العنوان: | Telomere length is a prognostic biomarker in elderly advanced ovarian cancer patients: a multicenter GINECO study |
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| المؤلفون: | Eric Pujade-Lauraine, Béatrice Horard, Jérôme Meunier, Jérôme Alexandre, Raymonde Maraval-Gaget, Michel Fabbro, Claire Falandry, Eric Legouffe, Eric Gilson, Gilles Freyer, Valérie Delecroix, Marie-Noëlle Certain, Amandine Bruyas, J. Cretin |
| المساهمون: | Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Epigénétique et formation du zygote, Département génétique, interactions et évolution des génomes [LBBE] (GINSENG), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Aging (Albany NY) Aging Aging, Impact Journals, 2015, 7 (12), pp.1066-76. ⟨10.18632/aging.100840⟩ Aging (Albany NY), 2015, 7 (12), pp.1066-76. ⟨10.18632/aging.100840⟩ Aging, 2015, 7 (12), pp.1066-76. ⟨10.18632/aging.100840⟩ |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Oncology, Aging, Time Factors, [SDV]Life Sciences [q-bio], Carboplatin, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, 80 and over, 10. No inequality, prognostic factor, Aged, 80 and over, Ovarian Neoplasms, 0303 health sciences, telomere, Carboplatin/*therapeutic use, Antineoplastic Agents/*therapeutic use, 3. Good health, ovarian cancer, 030220 oncology & carcinogenesis, Female, Research Paper, Senescence, medicine.medical_specialty, geriatric, Antineoplastic Agents, elderly, 03 medical and health sciences, Telomere Homeostasis, Internal medicine, medicine, Humans, Prognostic biomarker, 030304 developmental biology, Telomere Homeostasis/*physiology, Aged, Neoplasm Staging, business.industry, Cancer, Cell Biology, medicine.disease, Telomere, chemistry, Ovarian Neoplasms/drug therapy/*metabolism, Ovarian cancer, business, Biomarkers |
| الوصف: | International audience; PURPOSE: Age induces a progressive decline in functional reserve and impacts cancer treatments. Telomere attrition leads to tissue senescence. We tested the hypothesis that telomere length (TL) could predict patient vulnerability and outcome with cancer treatment. PATIENTS AND METHODS: An ancillary study in the Elderly Women GINECO Trial 3 was performed to evaluate the impact of geriatric covariates on survival in elderly advanced ovarian cancer patients receiving six cycles of carboplatin. TL was estimated from peripheral blood at inclusion using standard procedures. RESULTS: TL (in base pairs) was estimated for 109/111 patients (median 6.1 kb; range [4.5-8.3 kb]). With a cut-off of 5.77 kb, TL discriminated two patient groups, long telomere (LT) and short telomeres (ST), with significantly different treatment completion rates of 0.80 (95% CI [0.71-0.89]) and 0.59 (95% CI [0.41-0.76]), respectively (odds ratio [OR]=2.8, p=0.02). ST patients were at higher risk of serious adverse events (SAE, OR=2.7; p=0.02) and had more unplanned hospital admissions (OR=2.1; p=0.08). After adjustment on FIGO stage, TL shorter than 6 kb was a risk factor of premature death (HR=1.57; p=0.06). CONCLUSION: This exploratory study identifies TL as predictive factor of decreased treatment completion, SAE risk, unplanned hospital admissions and OS after adjustment on FIGO stage. |
| تدمد: | 1945-4589 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e2842be5465fd4b9295f07987d62c8Test https://pubmed.ncbi.nlm.nih.gov/26638179Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....80e2842be5465fd4b9295f07987d62c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19454589 |
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