Thiol/disulfide homeostasis and its relationship with insulin resistance in patients with rosacea
| العنوان: | Thiol/disulfide homeostasis and its relationship with insulin resistance in patients with rosacea |
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| المؤلفون: | Duygu Yazgan Aksoy, Suzan Demir Pektas, Ahmet Kara, Nese Cinar, Deniz Duman, Gulhan Akbaba, Salim Neselioglu, Gökhan Pektaş, Hilal Semra Hancer, Ozcan Erel |
| المصدر: | Journal of Cosmetic Dermatology. 21:2655-2661 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Dermatology, medicine.disease_cause, Pathogenesis, Insulin resistance, Internal medicine, medicine, Homeostasis, Humans, Disulfides, Prospective Studies, Sulfhydryl Compounds, Prospective cohort study, business.industry, Metabolic disorder, food and beverages, medicine.disease, Oxidative Stress, Endocrinology, Rosacea, Chronic Disease, Insulin Resistance, business, Body mass index, Biomarkers, Oxidative stress |
| الوصف: | Rosacea is a chronic inflammatory cutaneous disease that can be associated with cardiometabolic disorders. Oxidative stress is included in the pathogenesis of rosacea, and thiol-disulfide homeostasis (TDH) acts as antioxidants.To evaluate the TDH and metabolic parameters in patients with rosacea.A total of 42 rosacea patients and 50 controls participated in this prospective study. Demographic data, clinical entities, anthropometric measurements, and laboratory findings were recorded. Additionally, TDH was measured by an automated spectrophotometric method.Rosacea patients had greater body mass index values (27.9 ± 5.2 kg/m² vs. 23 ± 1.4 kg/m², p 0.001), waist-hip ratios (0.87 ± 0.1 vs. 0.77 ± 0.8, p 0.001), and insulin resistance (3.0 ± 2.0 vs. 1.3 ± 0.5, p 0.001) compared with controls. Disulfide levels, the disulfide/native thiol ratio (DNTR), and the disulfide/total thiol ratio (DTTR) were increased (p 0.05) in rosacea patients. Native thiol and total thiol levels and the native/total thiol ratio (NTTR) were decreased in rosacea patients (p 0.05). Different rosacea subtypes had no effect on oxidative stress markers. The duration of illness and insulin resistance values significantly correlated with DNTR and DTTR in the rosacea group (p 0.05).Rosacea has a metabolic milieu with increased oxidative stress and insulin resistance. |
| تدمد: | 1473-2165 1473-2130 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cb990c5bbb13acb5db9431f04346c2Test https://doi.org/10.1111/jocd.14477Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....80cb990c5bbb13acb5db9431f04346c2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732165 14732130 |
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