Opposing associations of serum n-3 and n-6 polyunsaturated fatty acids with colorectal adenoma risk: An endoscopy-based case-control study
| العنوان: | Opposing associations of serum n-3 and n-6 polyunsaturated fatty acids with colorectal adenoma risk: An endoscopy-based case-control study |
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| المؤلفون: | Gerda K. Pot, Else-Mariëtte B. van Heijningen, Henk J. van Kranen, Anouk Geelen, Ellen Kampman, Christine L.E. Siezen |
| المساهمون: | Health & Life, Health Sciences |
| المصدر: | International Journal of Cancer 123 (2008) 8 International Journal of Cancer, 123, 8, pp. 1974-7 International Journal of Cancer, 123(8), 1974-7. International Union Against Cancer Pot, G K, Geelen, A, van Heijningen, E M, Siezen, C L, van Kranen, H J & Kampman, E 2008, ' Opposing associations of serum n-3 and n-6 polyunsaturated fatty acids with colorectal adenoma risk: an endoscopy-based case-control study. ', International Journal of Cancer, vol. 123, no. 8, pp. 1974-7 . https://doi.org/10.1002/ijc.23729Test International Journal of Cancer, 123, 1974-7 International Journal of Cancer, 123(8), 1974-1977 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adenoma, Male, Cancer Research, medicine.medical_specialty, Nutrition and Disease, Aetiology, screening and detection [ONCOL 5], Colorectal adenoma, Endoscopy, Gastrointestinal, Molecular epidemiology [NCEBP 1], SDG 3 - Good Health and Well-being, Risk Factors, Translational research [ONCOL 3], Fatty Acids, Omega-6, Voeding en Ziekte, Internal medicine, Fatty Acids, Omega-3, medicine, Humans, cancer, Risk factor, Unsaturated fatty acid, VLAG, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], chemistry.chemical_classification, Hereditary cancer and cancer-related syndromes [ONCOL 1], business.industry, Case-control study, fish consumption, cohort, Odds ratio, Middle Aged, medicine.disease, Eicosapentaenoic acid, Endocrinology, Oncology, chemistry, Docosahexaenoic acid, Case-Control Studies, Female, lipids (amino acids, peptides, and proteins), women, Colorectal Neoplasms, business, Precancerous Conditions, Polyunsaturated fatty acid |
| الوصف: | Item does not contain fulltext Several human and animal studies have shown that n-3 polyunsaturated fatty acids (PUFA) might be associated with a decreased risk, whereas other studies showed that n-6 PUFA may be associated with an increased risk of colorectal cancer. However, results from these studies are not consistent. We evaluated the associations between serum n-3 and n-6 PUFA levels and colorectal adenoma risk in an endoscopy-based case-control study, conducted in The Netherlands between 1997 and 2002. We included 363 cases of colorectal adenomas and 498 adenoma-free controls. Serum fatty acids were measured in cholesteryl esters. Logistic regression models were used to calculate odds ratios (OR), which were adjusted for age, gender and alcohol intake. Total serum n-3 PUFA levels were inversely associated with colorectal adenoma risk, the OR comparing the third tertile with the first tertile was 0.67 [95% confidence interval (CI) 0.46-0.96, p for trend = 0.03]. Serum eicosapentaenoic acid (EPA; C20:5n-3) and docosahexaenoic acid (DHA; C22:6n-3) and the n-3/n-6 ratio were inversely associated with colorectal adenoma risk, but these were not statistically significant. In contrast, the risk of colorectal adenomas was increased by total n-6 PUFA with an OR of 1.68 (95% CI, 1.17-2.42, p for trend = 0.006) and by linoleic acid (LA; C18:2n-6) with an OR of 1.65 (95% CI, 1.15-2.38, p for trend = 0.007). This is the first observational study that simultaneously finds an inverse association of serum n-3 PUFA and a positive association of n-6 PUFA with colorectal adenoma risk. |
| وصف الملف: | application/pdf; application/octet-stream |
| تدمد: | 1097-0215 0020-7136 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8064bfdd5e1e7e520a7b66bc8c3fd4c5Test https://doi.org/10.1002/ijc.23729Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8064bfdd5e1e7e520a7b66bc8c3fd4c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
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