Haplotype association study betweenDRD1 gene and bipolar type I affective disorder in two samples from Canada and Sardinia
| العنوان: | Haplotype association study betweenDRD1 gene and bipolar type I affective disorder in two samples from Canada and Sardinia |
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| المؤلفون: | Giovanni Severino, Vincenzo De Luca, Donatella Congiu, Maria Paola Piccardi, Stefania Mulas, Xingqun Ni, Maria Del Zompo, James L. Kennedy |
| المصدر: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :237-241 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Proband, Canada, Candidate gene, Bipolar Disorder, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Cellular and Molecular Neuroscience, Risk Factors, medicine, Humans, Genetic Predisposition to Disease, Bipolar disorder, Gene, Alleles, Genetics (clinical), Genetic association, Genetics, Receptors, Dopamine D1, Haplotype, Control subjects, medicine.disease, Psychiatry and Mental health, Haplotypes, Italy, Case-Control Studies, Female |
| الوصف: | Based on the dopaminergic hypothesis, the dopamine D1 receptor gene (DRD1) is considered to be a good candidate gene involved in the susceptibility of bipolar disorder (BP). Genetic association between three DRD1 single nucleotide polymorphisms (SNPs) (−800T/C, −48A/G, and 1403T/C) and bipolar type I (BP I) disorder was performed in a case-control sample of Sardinian origin (170 BP I and 209 controls) and in an enlarged sample (229 families) of BP I trios from Toronto. The haplotype analyses generated significant global chi-square in both samples (P-value 0.024 in Toronto and 0.00042 in Sardinian). The main representative haplotypes in both samples were the −800T/−48A/1403C and the −800C/−48G/1403T. Considering each group individually, the −800C/−48G/1403T was transmitted more frequently from parents to BP I probands in Toronto sample (nominally P-value = 0.047) and was more frequent in cases than in control subjects in Sardinian sample although showing no significant evidence of association (nominally P-value = 0.16) When the estimated haplotype counts of both samples were combined, the global χ2 was significant (P-value = 0.00085) and the nominal P-value for the haplotype −800C/−48G/1403T was 0.01. The fact that the same haplotype shows a similar trend for association in samples originating from different ethnic backgrounds seems to imply that the −800C/−48G/1403T haplotype may be considered as a risk factor for BP I disorder. © 2006 Wiley-Liss, Inc. |
| تدمد: | 1552-485X 1552-4841 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801c457f7fcb503621b2c7c366a36e9bTest https://doi.org/10.1002/ajmg.b.30445Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....801c457f7fcb503621b2c7c366a36e9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1552485X 15524841 |
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