Abnormal short latency afferent inhibition in early Alzheimer’s disease: a transcranial magnetic demonstration
| العنوان: | Abnormal short latency afferent inhibition in early Alzheimer’s disease: a transcranial magnetic demonstration |
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| المؤلفون: | Stefanie Klein, Jürgen Bergmann, Alexander Kunz, Stefan Golaszewski, Martin Kronbichler, Gunther Ladurner, Raffaele Nardone, Frediano Tezzon, Francesca Caleri |
| المصدر: | Journal of Neural Transmission. 115:1557-1562 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Neurology, medicine.medical_treatment, Disease, Pathogenesis, Alzheimer Disease, Parasympathetic Nervous System, Afferent, Peripheral Nervous System, medicine, Humans, Short latency, Biological Psychiatry, Aged, Psychiatric Status Rating Scales, Electroshock, Motor Cortex, Middle Aged, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, Psychiatry and Mental health, medicine.anatomical_structure, Cholinergic, Female, Neurology (clinical), Psychology, Neuroscience, Motor cortex |
| الوصف: | The pathogenesis of Alzheimer's disease (AD) appears to involve several different mechanisms, the most consistent of which is an impairment of cholinergic neurotransmission; however, there is controversy about its relevance at the early stage of disease. A transcranial magnetic stimulation (TMS) protocol based on coupling peripheral nerve stimulation with motor cortex TMS (short latency afferent inhibition, SAI) may give direct information about the function of some cholinergic pathways in the human motor cortex. We evaluated SAI in a group of patients with early diagnosis of AD and compared the data with that from a control group. The amount of SAI was significantly smaller in early AD patients than in controls. This study first provides physiological evidence that a central cholinergic dysfunction occurs in the earlier stages of AD. Identification of SAI abnormalities that occur early in the course of AD will allow earlier diagnosis and treatment with cholinergic drugs. |
| تدمد: | 1435-1463 0300-9564 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80087ed2dad0791c3705e28052a1915aTest https://doi.org/10.1007/s00702-008-0129-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....80087ed2dad0791c3705e28052a1915a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14351463 03009564 |
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