CACNA1C rs1006737 SNP increases the risk of essential hypertension in both Chinese Han and ethnic Russian people of Northeast Asia
| العنوان: | CACNA1C rs1006737 SNP increases the risk of essential hypertension in both Chinese Han and ethnic Russian people of Northeast Asia |
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| المؤلفون: | Hao Zhang, Boris Pushkarev, Mingyu Cong, Ming Jin, Changchun Qiu, Keyong Zhang, Yuri Vitkovsky, Baiyu Jian, Ningning Wang, Jicheng Liu, Olga Bolshakova, Sandeep Shrestha, Yuyuan Mu, Jiexin Zhou |
| المصدر: | Medicine |
| بيانات النشر: | Lippincott Williams & Wilkins, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Genetic Markers, Male, China, Calcium Channels, L-Type, Chinese Han and ethnic Russian people, Ethnic group, Observational Study, Essential hypertension, Polymorphism, Single Nucleotide, White People, CACNA1C gene, Russia, specific latitudes, 03 medical and health sciences, 0302 clinical medicine, Asian People, Risk Factors, Genotype, Humans, Medicine, genetics, 030212 general & internal medicine, Allele, Risk factor, Alleles, business.industry, Case-control study, essential hypertension, General Medicine, Odds ratio, Middle Aged, medicine.disease, Minor allele frequency, biracial study, Case-Control Studies, 030220 oncology & carcinogenesis, Female, business, Demography, Research Article |
| الوصف: | Voltage-gated Ca2+ channels play a key role in the regulation of arterial tone and blood pressure. The aim of this study was to determine whether the association of calcium voltage-gated channel subunit alpha1 C (CACNA1C) rs1006737 with essential hypertension (EH) exists in both Chinese Han and ethnic Russian populations of Northeast Asia. We used a case-control study of 2 ethnic groups in the same latitude geographical area to investigate the association between the susceptibility of EH and rs1006737 polymorphism. A total of 1512 EH patients and 1690 controls in Chinese Han people (Heilongjiang Provence, China), 250 EH patients, and 250 controls in ethnic Russian people (Chita, Russia), participated in this study. All participants were genotyped using the TaqMan SNP genotyping assay (Agena Company). Baseline characteristics and the minor allele frequencies of rs1006737 vary substantially among common Chinese Han and ethnic Russian people. Allele A was found to be a risk factor for EH in Chinese Han [(odds ratio) OR 1.705, (confidence interval) 95% CI: 1.332-2.182, P |
| اللغة: | English |
| تدمد: | 1536-5964 0025-7974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fefb7870c9f2bf592706cf9e0fc41fcTest http://europepmc.org/articles/PMC7909128Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7fefb7870c9f2bf592706cf9e0fc41fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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