Impaired glucagon secretion in patients with fulminant type 1 diabetes mellitus
| العنوان: | Impaired glucagon secretion in patients with fulminant type 1 diabetes mellitus |
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| المؤلفون: | Wataru Ogawa, Yoko Okuno, Kazuhiko Sakaguchi, Yushi Hirota, Hisako Komada, Susumu Seino |
| المصدر: | Endocrine. 63:476-479 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Fulminant, 030209 endocrinology & metabolism, Glucagon, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, Type 1 diabetes, business.industry, Pancreatic islets, Glucagon secretion, nutritional and metabolic diseases, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, Pathophysiology, Diabetes Mellitus, Type 1, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, business |
| الوصف: | Fulminant type 1 diabetes mellitus (FT1DM), characterized by rapid and almost complete destruction of pancreatic β-cells, is a newly identified subtype of type 1 diabetes mellitus. Although, the pathophysiology of this condition remains still unclear, histological evidence suggests that not only β-cells but also α-cells of pancreatic islets are reduced in number in FT1DM. However, the ability of glucagon secretion in patients with this condition has remained largely uncharacterized. We therefore examined glucagon secretion in patients with FT1DM and compared that with patients with other types of diabetes mellitus. Fasting glucagon levels as well as glucagon secretion induced by intravenous administration of arginine were measured in hospitalized 83 patients with diabetes mellitus, including 4 with FT1DM, 18 with type 1 diabetes mellitus (T1DM), 40 with type 2 diabetes mellitus (T2DM), 5 with slowly progressive insulin-dependent diabetes mellitus (SPIDDM), and 16 with pancreatic diabetes mellitus (PDM). The area under the curve for serum glucagon levels after arginine infusion in FT1DM patients was significantly smaller than that in T1DM, T2DM, or SPIDDM patients but was similar to that in PDM patients. The fasting serum glucagon level of FT1DM patients was lower than that of T1DM or T2DM patients but did not significantly differ from that of SPIDDM or PDM patients. These results suggest that glucagon secretion is impaired in patients with FT1DM. |
| تدمد: | 1559-0100 1355-008X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe50c26b5684efb6472656decbfc556Test https://doi.org/10.1007/s12020-018-1750-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7fe50c26b5684efb6472656decbfc556 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590100 1355008X |
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