Receptor-Dependent and Independent Regulation of Voltage-Gated Ca2+ Channels and Ca2+-Permeable Channels by Endocannabinoids in the Brain
| العنوان: | Receptor-Dependent and Independent Regulation of Voltage-Gated Ca2+ Channels and Ca2+-Permeable Channels by Endocannabinoids in the Brain |
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| المؤلفون: | Tomasz Boczek, Ludmila Zylinska |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 8168, p 8168 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cannabinoid receptor, QH301-705.5, Neurotransmission, Catalysis, Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, cannabinoid receptors, calcium channels, synaptic transmission, Physical and Theoretical Chemistry, endocannabinoids, Biology (General), Molecular Biology, QD1-999, Spectroscopy, G protein-coupled receptor, calcium, Voltage-gated ion channel, Voltage-dependent calcium channel, Chemistry, Organic Chemistry, General Medicine, Anandamide, Endocannabinoid system, Computer Science Applications, 030104 developmental biology, Signal transduction, Neuroscience, 030217 neurology & neurosurgery, signal transduction |
| الوصف: | The activity of specific populations of neurons in different brain areas makes decisions regarding proper synaptic transmission, the ability to make adaptations in response to different external signals, as well as the triggering of specific regulatory pathways to sustain neural function. The endocannabinoid system (ECS) appears to be a very important, highly expressed, and active system of control in the central nervous system (CNS). Functionally, it allows the cells to respond quickly to processes that occur during synaptic transmission, but can also induce long-term changes. The endocannabinoids (eCBs) belong to a large family of bioactive lipid mediators that includes amides, esters, and ethers of long-chain polyunsaturated fatty acids. They are produced “on demand” from the precursors located in the membranes, exhibit a short half-life, and play a key role as retrograde messengers. eCBs act mainly through two receptors, CB1R and CB2R, which belong to the G-protein coupled receptor superfamily (GPCRs), but can also exert their action via multiple non-receptor pathways. The action of eCBs depends on Ca2+, but eCBs can also regulate downstream Ca2+ signaling. In this short review, we focus on the regulation of neuronal calcium channels by the most effective members of eCBs-2-arachidonoylglycerol (2-AG), anandamide (AEA) and originating from AEA-N-arachidonoylglycine (NAGly), to better understand the contribution of ECS to brain function under physiological conditions. |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd71c471dac4822a532489913dc33a4Test https://www.mdpi.com/1422-0067/22/15/8168Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7fd71c471dac4822a532489913dc33a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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