Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients
| العنوان: | Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients |
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| المؤلفون: | D’Onofrio Nunzia, Pieretti Gorizio, Ciccarelli Feliciano, Gambardella Antonio, Passariello Nicola, Rizzo Maria Rosaria, Barbieri Michelangela, Marfella Raffaele, Nicoletti Giovanni Francesco, Balestrieri Maria Luisa, Sardu Celestino, D'ONOFRIO, NUNZIA |
| المساهمون: | D’Onofrio, Nunzia, Pieretti, Gorizio, Ciccarelli, Feliciano, Gambardella, Antonio, Passariello, Nicola, Rizzo, Maria Rosaria, Barbieri, Michelangela, Marfella, Raffaele, Nicoletti, Giovanni Francesco, Balestrieri, Maria Luisa, Sardu, Celestino, D'Onofrio, Nunzia |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 5, p 1153 (2019) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, obesity, medicine.medical_treatment, Adipose tissue, sirtuin 6, 030204 cardiovascular system & hematology, Overweight, NF-κB, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Sirtuins, Prospective Studies, lcsh:QH301-705.5, Spectroscopy, biology, Communication, Nitrotyrosine, Pre-diabete, NF-kappa B, General Medicine, Middle Aged, Metformin, Computer Science Applications, Female, medicine.symptom, Sterol Regulatory Element Binding Protein 1, medicine.drug, Adult, medicine.medical_specialty, PPAR-γ, Abdominal Fat, Down-Regulation, Catalysis, Prediabetic State, Inorganic Chemistry, 03 medical and health sciences, Insulin resistance, pre-diabetes, Internal medicine, medicine, Humans, Physical and Theoretical Chemistry, Interleukin 6, Molecular Biology, SREBP-1, business.industry, Insulin, Organic Chemistry, C-reactive protein, medicine.disease, PPAR gamma, 030104 developmental biology, Endocrinology, chemistry, lcsh:Biology (General), lcsh:QD1-999, biology.protein, business |
| الوصف: | The role of sirtuin 6 (SIRT6) in adipose abdominal tissue of pre-diabetic (pre-DM) patients is poorly known. Here, we evaluated SIRT6 expression in visceral abdominal fat of obese pre-diabetic patients and the potential effects of metformin therapy. Results indicated that obese pre-DM subjects showed low SIRT6 protein expression and high expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), peroxisome proliferator-activated receptor gamma (PPAR-γ), and sterol regulatory element-binding transcription factor 1 (SREBP-1). Obese pre-DM patients showed high values of glucose, insulin resistance (HOMA-IR), C reactive protein (CRP), nitrotyrosine, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), and low values of insulin (p < 0.05). Of note, abdominal fat tissue of obese pre-DM patients treated with metformin therapy presented higher SIRT6 expression and lower NF-κB, PPAR-γ, and SREBP-1 expression levels compared to pre-DM control group. Collectively, results show that SIRT6 is involved in the inflammatory pathway of subcutaneous abdominal fat of obese pre-DM patients and its expression responds to metformin therapy. The role of sirtuin 6 (SIRT6) in adipose abdominal tissue of pre-diabetic (pre-DM) patients is poorly known. Here, we evaluated SIRT6 expression in visceral abdominal fat of obese pre-diabetic patients and the potential effects of metformin therapy. Results indicated that obese pre-DM subjects showed low SIRT6 protein expression and high expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), peroxisome proliferator-activated receptor gamma (PPAR-γ), and sterol regulatory element-binding transcription factor 1 (SREBP-1). Obese pre-DM patients showed high values of glucose, insulin resistance (HOMA-IR), C reactive protein (CRP), nitrotyrosine, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), and low values of insulin (p < 0.05). Of note, abdominal fat tissue of obese pre-DM patients treated with metformin therapy presented higher SIRT6 expression and lower NF-κB, PPAR-γ, and SREBP-1 expression levels compared to pre-DM control group. Collectively, results show that SIRT6 is involved in the inflammatory pathway of subcutaneous abdominal fat of obese pre-DM patients and its expression responds to metformin therapy. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcc7ffbd9412af4d9178c88fd750498Test http://www.mdpi.com/1422-0067/20/5/1153Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7fcc7ffbd9412af4d9178c88fd750498 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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