Functional impairment‐based segmentation of anterior cingulate cortex in depression and its relationship with treatment effects
| العنوان: | Functional impairment‐based segmentation of anterior cingulate cortex in depression and its relationship with treatment effects |
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| المؤلفون: | Xinyi Wang, Cong Pei, Yujie Zhang, Qing Lu, Shuqiang Zhang, Haiyan Liu, Zhilu Chen, Junneng Shao, Zhijian Yao |
| المصدر: | Human Brain Mapping |
| بيانات النشر: | John Wiley & Sons, Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Functional impairment, computer.software_genre, 0302 clinical medicine, Dorsolateral Prefrontal Cortex, Voxel, Outcome Assessment, Health Care, Medicine, Depression (differential diagnoses), Research Articles, Radiological and Ultrasound Technology, major depressive disorders, 05 social sciences, Middle Aged, Amygdala, Magnetic Resonance Imaging, anterior cingulate cortex, medicine.anatomical_structure, Neurology, Antidepressant, Major depressive disorder, functional MRI, Female, Anatomy, unsupervised machine learning, psychological phenomena and processes, Research Article, Adult, behavioral disciplines and activities, Gyrus Cinguli, 050105 experimental psychology, antidepressive agents, 03 medical and health sciences, Young Adult, mental disorders, Connectome, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Anterior cingulate cortex, Depressive Disorder, Major, Resting state fMRI, business.industry, segmentation, medicine.disease, Dorsolateral prefrontal cortex, nervous system, Neurology (clinical), business, Neuroscience, computer, 030217 neurology & neurosurgery |
| الوصف: | In major depressive disorder (MDD), the anterior cingulate cortex (ACC) is widely related to depression impairment and antidepressant treatment response. The multiplicity of ACC subdivisions calls for a fine‐grained investigation of their functional impairment and recovery profiles. We recorded resting state fMRI signals from 59 MDD patients twice before and after 12‐week antidepressant treatment, as well as 59 healthy controls (HCs). With functional connectivity (FC) between each ACC voxel and four regions of interests (bilateral dorsolateral prefrontal cortex [DLPFC] and amygdalae), subdivisions with variable impairment were identified based on groups' dissimilarity values between MDD patients before treatment and HC. The ACC was subdivided into three impairment subdivisions named as MedialACC, DistalACC, and LateralACC according to their dominant locations. Furthermore, the impairment pattern and the recovery pattern were measured based on group statistical analyses. DistalACC impaired more on its FC with left DLPFC, whereas LateralACC showed more serious impairment on its FC with bilateral amygdalae. After treatment, FCs between DistalACC and left DLPFC, and between LateralACC and right amygdala were normalized while impaired FC between LateralACC and left amygdala kept dysfunctional. Subsequently, FC between DistalACC and left DLPFC might contribute to clinical outcome prediction. Our approach could provide an insight into how the ACC was impaired in depression and partly restored after antidepressant treatment, from the perspective of the interaction between ACC subregions and critical frontal and subcortical regions. This article identified the subregions of the anterior cingulate cortex with variable impairment in major depressive disorder patients and investigated the restoration pattern of subregions after antidepressant treatment. |
| اللغة: | English |
| تدمد: | 1097-0193 1065-9471 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f98da45aed44ae9385c58593ab052e8Test http://europepmc.org/articles/PMC8288091Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7f98da45aed44ae9385c58593ab052e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970193 10659471 |
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