Predictors of long-term tumor control after stereotactic radiosurgery for Koos grade 4 vestibular schwannomas
| العنوان: | Predictors of long-term tumor control after stereotactic radiosurgery for Koos grade 4 vestibular schwannomas |
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| المؤلفون: | Takenori Kato, Risa Ito, Kou Okada, Toshinori Hasegawa, Takafumi Tanei, Eisuke Tsukamoto, Kazuki Ishii, Takehiro Naito, Yuuta Kouketsu |
| المصدر: | Journal of Neuro-Oncology. 151:145-156 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Neurology, Adolescent, medicine.medical_treatment, Radiosurgery, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Trigeminal neuralgia, medicine, Middle cerebellar peduncle, Humans, Aged, Aged, 80 and over, Palsy, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Neuroma, Acoustic, Middle Aged, Prognosis, Tumor control, medicine.disease, Tumor Burden, Hydrocephalus, Survival Rate, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Female, Neurology (clinical), business, Nuclear medicine, 030217 neurology & neurosurgery, Follow-Up Studies |
| الوصف: | To evaluate the predictors of long-term tumor control following stereotactic radiosurgery (SRS) for Koos grade 4 vestibular schwannomas (VSs).Overall, 203 sporadic VS patients with compression of the brainstem were treated with SRS. The median tumor volume was 6.7 cmThe median follow-up period was 152 months (range, 12-277 months). Tumor control (TC) rates at 3, 5, and 10 years were 89%, 85%, and 82%, respectively. Operation-free survival (OFS) rates at 3, 5, and 10 years were 92%, 85%, and 83%, respectively. Middle cerebellar peduncle (MCP) compression on pre-SRS magnetic resonance imaging scans was significant for both TC (p 0.001, hazard ratio 1.332) and OFS (p 0.001, hazard ratio 1.306). The 3-, 5-, and 10-year OFS rates were 98%, 94%, and 92% in the low-risk group (MCP compression 9.8 mm and 48 years old), and 58%, 25%, and 17% in high-risk group (MCP compression ≥ 9.8 mm and ≤ 48 years old), respectively. Ten patients (4.9%) developed delayed cyst-related complications. Eleven patients (5.4%) developed newly developed or worsened trigeminal neuralgia. No patient developed persistent facial palsy as an adverse radiation effect. A ventricular peritoneal shunt was required in six patients (3%) who developed hydrocephalus after SRS.SRS is an acceptable treatment option in selected patients with Koos grade 4 VSs. Risk group classification based on patient age and MCP compression is useful in decision-making of Koos grade 4 VSs. |
| تدمد: | 1573-7373 0167-594X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6e933456ba7d90f1cb7a84adb7c463Test https://doi.org/10.1007/s11060-020-03622-5Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7f6e933456ba7d90f1cb7a84adb7c463 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737373 0167594X |
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