Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease
| العنوان: | Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease |
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| المؤلفون: | Lene Wermuth, Henrik Zetterberg, Kaj Blennow, Gunhild Waldemar, Camilla Steen Jensen, Erik Portelius, Volkert Siersma, Steen G. Hasselbalch, Anja Hviid Simonsen, Peter Høgh |
| المصدر: | Steen Jensen, C, Portelius, E, Siersma, V, Høgh, P, Wermuth, L, Blennow, K, Zetterberg, H, Waldemar, G, Gregers Hasselbalch, S & Hviid Simonsen, A 2016, ' Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate-to High-Intensity Physical Exercise in Patients with Alzheimer Disease ', Dementia and Geriatric Cognitive Disorders, vol. 42, no. 3-4, pp. 146-158 . https://doi.org/10.1159/000449408Test |
| بيانات النشر: | S. Karger AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Genotype, Amyloid, Amyloid beta, Cognitive Neuroscience, Apolipoprotein E4, tau Proteins, Physical exercise, Amyloid beta-Protein Precursor, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Alzheimer Disease, Internal medicine, medicine, Humans, Dementia, In patient, Exercise, Aged, Amyloid beta-Peptides, biology, business.industry, High intensity, Middle Aged, Phosphoproteins, medicine.disease, Peptide Fragments, Exercise Therapy, Psychiatry and Mental health, 030104 developmental biology, Endocrinology, Quality of Life, biology.protein, Female, Geriatrics and Gerontology, Alzheimer's disease, business, Neuroscience, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | Background: Physical exercise may have some effect on cognition in patients with Alzheimer disease (AD). However, the underlying biochemical effects are unclear. Animal studies have shown that amyloid beta (Aβ), one of the pathological hallmarks of AD, can be altered with high levels of physical activity. Aim: The objective of this study was to elucidate the effect of 16 weeks of moderate- to high-intensity physical exercise on the biomarkers of AD, with special emphasis on the amyloidogenic pathway. Methods: From a total of 53 patients with AD participating in the Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study we analyzed cerebrospinal fluid samples for Aβ species, total tau (t-tau), phosphorylated tau (p-tau) and soluble amyloid precursor protein (sAPP) species. We also assessed the patients for apolipoprotein E ε4 (ApoE ε4) genotype. Results: We found no effect of 16 weeks of physical exercise on the selected biomarkers, and no effect of ApoE ε4 genotype. Conclusion: Our findings suggest that the possible effect of physical exercise on cognition in patients with AD is not due to modulation of Aβ, t-tau, p-tau and sAPP species. |
| تدمد: | 1421-9824 1420-8008 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0da936d57165d381e71723651d6e8bTest https://doi.org/10.1159/000449408Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7f0da936d57165d381e71723651d6e8b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219824 14208008 |
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