Specific Features of Immediate Ultrastructural Changes in Brain Cortex Mitochondria of Rats with Different Tolerance to Hypoxia under Various Modes of Hypoxic Exposures
| العنوان: | Specific Features of Immediate Ultrastructural Changes in Brain Cortex Mitochondria of Rats with Different Tolerance to Hypoxia under Various Modes of Hypoxic Exposures |
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| المؤلفون: | I. B. Mikheeva, L. D. Luk'yanova, L. L. Pavlik, Yu. I. Kirova, V. P. Berest, E. L. Germanova, Galina D. Mironova, Ya. M. Al’-Mugkhrabi |
| المصدر: | Bulletin of Experimental Biology and Medicine. 164:376-381 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Cell, Prefrontal Cortex, Altitude Sickness, Mitochondrion, Matrix (biology), General Biochemistry, Genetics and Molecular Biology, Tissue Culture Techniques, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Animals, Outbred Strains, medicine, Animals, Prefrontal cortex, Chemistry, Brain cortex, Microtomy, General Medicine, Hypoxia (medical), Adaptation, Physiological, Mitochondria, Rats, Oxygen, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Cerebral cortex, Ultrastructure, medicine.symptom, 030217 neurology & neurosurgery |
| الوصف: | We performed ultrastructural study of cerebral cortex mitochondria in rats with different tolerance to oxygen deficiency (low resistant and highly resistant specimens). Low resistant rats were characterized by the prevalence of mitochondria with lightened matrix due to the nondense packing of cristae. By contrast, mitochondria of highly resistant animals had the dense packing of cristae. The structure of mitochondria underwent adaptive changes at 14-10% O2 in the inspired air. Under these conditions, structural characteristics of the cerebral cortex in hypoxia-sensitive rats resembled those in resistant animals. The decrease in O2 concentration to 8% was accompanied by ultrastructural signs of mitochondrial damage, which correlated with de-energization of the cell and dysfunction of adaptive signaling systems. Ultrastructural features of cerebral cortex mitochondria in animals with low and high tolerance to acute oxygen deficiency confirm the hypothesis that they are associated with two different "functionaland-metabolic portraits". |
| تدمد: | 1573-8221 0007-4888 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ead415fe5f360baa7faa318d7db3e7aTest https://doi.org/10.1007/s10517-018-3993-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7ead415fe5f360baa7faa318d7db3e7a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15738221 00074888 |
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