Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis
| العنوان: | Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis |
|---|---|
| المؤلفون: | Shin‐ichi Miyajima, Akio Mitani, Yuki Suzuki, Nobuhisa Nakamura, Keiko Naruse, Noritaka Sawada, Megumi Miyabe, Takeshi Kikuchi, Tatsuaki Matsubara, Masaki J. Honda, Shuichiro Kobayashi, Kei Adachi, Makoto Mizutani, Taku Toriumi, Mizuho Ito |
| المصدر: | Journal of Diabetes Research, Vol 2020 (2020) Journal of Diabetes Research |
| بيانات النشر: | Hindawi Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Agonist, Male, Periodontium, medicine.medical_specialty, Article Subject, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Alveolar Bone Loss, Gingiva, Gene Expression, Osteoclasts, 030209 endocrinology & metabolism, Glucagon-Like Peptide-1 Receptor, Diseases of the endocrine glands. Clinical endocrinology, Proinflammatory cytokine, Diabetes Complications, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Alveolar Process, Maxilla, Animals, Hypoglycemic Agents, Periodontitis, Ligation, Dental alveolus, Glucagon-like peptide 1 receptor, Inflammation, Liraglutide, business.industry, Macrophages, 030206 dentistry, X-Ray Microtomography, medicine.disease, RC648-665, Maxillary Diseases, Rats, Cytokines, Tumor necrosis factor alpha, business, Research Article, medicine.drug |
| الوصف: | Periodontitis is one of the diabetic complications due to its high morbidity and severity in patients with diabetes. The prevention of periodontitis is especially important in diabetic patients because the relationship between diabetes and periodontitis is bidirectional. Here, we evaluated the impacts of glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on the amelioration of periodontitis. Five-wk-old Male Sprague–Dawley (SD) rats ( n = 30 ) were divided into 3 groups: normal, periodontitis, and periodontitis with liraglutide treatment groups. Periodontitis was induced by ligature around the maxillary second molar in SD rats. Half of the rats were administered liraglutide for 2 weeks. Periodontitis was evaluated by histological staining, gene expressions of inflammatory cytokines in gingiva, and microcomputed tomography. Periodontitis increased inflammatory cell infiltration, macrophage accumulation, and gene expressions of tumor necrosis factor-α and inducible nitric oxide synthase in the gingiva, all of which were ameliorated by liraglutide. Liraglutide decreased M1 macrophages but did not affect M2 macrophages in periodontitis. Moreover, ligature-induced alveolar bone resorption was ameliorated by liraglutide. Liraglutide treatment also reduced osteoclasts on the alveolar bone surface. These results highlight the beyond glucose-lowering effects of liraglutide on the treatment of periodontitis. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6753 2314-6745 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea98118a3cae21255a989772110ea63Test https://doaj.org/article/c6cfd4fd1cbe4a96a59e36a36c087bb5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7ea98118a3cae21255a989772110ea63 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146753 23146745 |
|---|